Results 121 to 130 of about 5,531,484 (250)

Improvement in Functional Outcome from 6 to 12 Months After Moderate and Severe Traumatic Brain Injury Is Frequent, But May Not Be Detected With the Glasgow Outcome Scale Extended

Neurotrauma Reports
The aims of this study were (1) to report outcome and change in outcome in patients with moderate and severe traumatic brain injury (mo/sTBI) between 6 and 12 months post-injury as measured by the Glasgow Outcome Scale Extended (GOSE), (2) to explore if ...
Rabea Iris Pantelatos, Jonas Stenberg, Turid Follestad, Oddrun Sandrød, Cathrine Elisabeth Einarsen, Anne Vik, Toril Skandsen   +6 more
doaj   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cognitive deterioration in adult epilepsy: clinical characteristics of "Accelerated Cognitive Ageing"

, 2016
ObjectivesEpileptic dementia is reported in adults with childhood-onset refractory epilepsy. Cognitive deterioration can also occur in a second-hit model.
Mestrom, RMC, D. C. W. Klooster, Grevers, E, S. Zinger, Aldenkamp, AP Albert, Besseling, RMH, Aldenkamp, A. P., Mestrom, RMC Rob, Aldenkamp, Albert, Breuer, L., Besseling, RMH René, Zinger, S, de Louw, A., de Louw, A.J.A., Zinger, S Sveta, L. E. M. Breuer, Bernas, A, Mestrom, R. M. C., K. Vonck, Boon, P Paul, R. M. C. Mestrom, Besseling, R. M. H., Bergmans, JWM Jan, Boon, P., J. W. M. Bergmans, E. Grevers, Breuer, L. E. M., Aldenkamp, A.P., Breuer, LEM, Klooster, DCW, Boon, Paul, Bernas, A., Vonck, Kristl, Bergmans, JWM, A. Bernas, Boon, Paul A.J.M., de Louw, A, Besseling, R.M.H., Vonck, KEJ, Bergmans, J. W. M., Grevers, E., Klooster, DCW Debby, Mestrom, R.M.C.; id_orcid, P. Boon, Klooster, D.C.W., Zinger, S., Vonck, K., R. M. H. Besseling, Louw, AJA Anton de, Klooster, D. C. W., A. P. Aldenkamp, Bergmans, J.W.M., Mestrom, R.M.C., A. de Louw   +53 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Diagnosis and staging of patients with ovarian cancer: National Clinical Guideline No. 20 Annex 1: Systematic review of cost effectiveness

, 2018
The purpose of this systematic review was to identify and evaluate economic evidence to inform the clinical recommendations of this NCG. Review of the cost-effectiveness of health technologies enables guideline developers to explicitly consider how ...
HRB-CICER (Collaboration in Ireland for Clinical Effectiveness Reviews)
core  

COVID-19 Infection—Preventing Clinical Deterioration [PDF]

JAMA, 2020
Seymour, Christopher W., Bauchner, Howard, Golub, Robert M.   +2 more
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Advance care planning in the context of clinical deterioration: a systematic review of the literature

, 2019
A Rapid Response Team can respond to critically ill patients in hospital to prevent further deterioration and unexpected deaths. However, approximately one-third of reviews involve a patient approaching the end-of-life.
O'Neill, M, Florin Oprescu, Goodman, S, Goodman, Sarah, Pearse, W, O’Neill, M, Oprescu, F I, Hyde, M, Maureen O’Neill, Endacott, J, Sarah Goodman, John Endacott, Mervyn Hyde, Pearse, Wendy, Hyde, M B, Wendy Pearse, Endacott, John, Oprescu, F   +17 more
core   +1 more source