Results 101 to 110 of about 685,546 (303)

Progression of GBA1 severe and risk variants: a longitudinal mixed model analysis

Frontiers in Aging Neuroscience
IntroductionAn association between severe GBA1 variants and the progression of non-motor symptoms in PD has been reported, but the role of Parkinson’s-risk (PD-risk) GBA1 variants is less clear.MethodsWe assessed symptom progression in individuals with ...
Anne-Marie Hanff, Anne-Marie Hanff, Anne-Marie Hanff, Anne-Marie Hanff, Christopher McCrum, Armin Rauschenberger, Sinthuja Pachchek, Gloria A. Aguayo, Claire Pauly, Claire Pauly, Claire Pauly, Sonja R. Jónsdóttir, Sonja R. Jónsdóttir, Sonja R. Jónsdóttir, Olena Tsurkalenko, Olena Tsurkalenko, Olena Tsurkalenko, Olena Tsurkalenko, Laure Pauly, Laure Pauly, Laure Pauly, Zied Landoulsi, Zied Landoulsi, Anja K. Leist, Patrick May, Maurice P. Zeegers, Rejko Krüger, Rejko Krüger, Rejko Krüger   +28 more
doaj   +1 more source

Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation [PDF]

, 2017
Purpose Cough is common in chronic obstructive pulmonary disease (COPD) and is associated with frequent exacerbations and increased mortality. Cough increases during acute exacerbations (AE-COPD), representing a possible metric of clinical deterioration.
Crooks, Michael G., den Brinker, Albertus, Hayman, Yvette, Hill, Peter, Innes, Andrew, Morice, Alyn H., Williamson, James D., Wright, Caroline E.   +7 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Continuous Vital Signs Monitoring with a Wireless and Wearable Earsensor in Surgical Patients: A Clinical Validation Study

Sensors
(1) Background: Evidence on the clinical accuracy of wireless photoplethysmography (PPG)-based vital sign monitoring is limited. This study evaluated the accuracy, technical performance, and patient comfort of a novel PPG-based earsensor for measuring ...
Patrick van den Berge, Kim van Loon, Lianne Zevenbergen, Pascalle A. van den Heuvel, Martine J. M. Breteler   +4 more
doaj   +1 more source

Studies on the rejection of the transplanted homologous dog liver. [PDF]

, 1961
Dogs in which livers have been replaced with hepatic homografts usually die in 5 to 10 days. Liver metabolism is not detectably abnormal at first, but gradual deterioration of function commences on the fourth or fifth day.
BROCK, DR, KAUPP, HA, LINMAN, JW, STARZL, TE   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Predicting Deterioration in Patients With Normotensive Acute Pulmonary Embolism Using Clinical‐Imaging Features: A Multicenter Prospective Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Prioritization of management strategies in patients with normotensive acute pulmonary embolism is based on the identification of individuals at risk for early deterioration.
Yizhuo Gao, Shibo Wei, Yuchen Liu, Zhenglun Yu, Shanshan Zhan, Binze Yang, Chuanxin Qi, Shougang Qi, Minggang Wang, Dong Jia   +9 more
doaj   +1 more source

MRI Deterioration in Herpes Simplex Encephalitis Despite Clinical Recovery

The Neurologist, 2009
Herpes simplex virus type 1 is a sporadic cause of viral encephalitis. Relapse of encephalitis occurs in up to 10% of patients, manifested by recurrent symptoms, clinical and MRI findings, and the presence of herpes simplex virus type 1 DNA in the cerebrospinal fluid (CSF).We describe the clinical features, MRI findings and outcome in 2 patients with ...
Markoula, S., Giannopoulos, S., Pelidou, S. H., Argyropoulou, M., Lagos, G., Kyritsis, A. P.   +5 more
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Predictors of in-hospital mortality in patients requiring transfer to the medical intensive care unit

Journal of the Pakistan Medical Association
Objective: To identify the factors associated with higher odds of in-hospital mortality among inpatients requiring transfer to the medical intensive care unit.
Huzefa Jibril, Muhammad Azhar, Ainan Arshad, Safia Awan, Syed Ahsan Ali, Muhammed Tariq   +5 more
doaj   +1 more source