Results 121 to 130 of about 592,446 (323)

Tree shrew model of early diabetic retinopathy reveals microvascular dysfunction and identifies phosphoserine aminotransferase 1 as a novel therapeutic target

Animal Models and Experimental Medicine, EarlyView.
We developed an animal model of early diabetic retinopathy (DR) in the tree shrew by feeding a high‐fat and high‐sugar diet in combination with STZ. Physiological and biochemical index detection, hematoxylin and eosin staining, and transmission electron microscopy were performed to examine DR.
Min Qiu, Shurui Huo, Wenguang Wang, Na Li, Qingwei Zeng, Xiaomei Sun, Jiejie Dai, Pinfen Tong, Yuanyuan Han, Ling Zhao, Caixia Lu   +10 more
wiley   +1 more source

Surgical menopause and frailty risk in older community dwelling women: the study of osteoporotic fractures [PDF]

, 2016
BACKGROUND: Low testosterone levels in older women have been shown to be associated with frailty. Whether older postmenopausal women with a history of bilateral oophorectomy before natural menopause resulting in lower testosterone levels (surgical ...
Huang, Grace
core   +1 more source

Optimization and verification of high‐fat diet formulation for establishing a rat model of obesity‐related precocious puberty

Animal Models and Experimental Medicine, EarlyView.
We identified 45% HFD as the optimal formulation to establish a juvenile rat model of obesity‐related precocious puberty. It elicits robust phenotypic (early vaginal opening, obesity), histological (advanced ovarian development), and endocrine (elevated HPG axis hormones) alterations, with leptin‐mediated GnRH secretion as a core mechanistic driver ...
Jiayi Gong, Wei Qian, Deji Song, Kang Li, Li Zhang, Li Shi   +5 more
wiley   +1 more source

Abstracts from the Translational Reproductive Biology and Clinical Reproductive Endocrinology Conference held Novembrer 17–20, 2016 [PDF]

, 2016
Mahnaz Motamedi, Effat Merghati-Khoei, Farideh Khalajabadi- Farahani, Shahrzad Rahimi-Neghani, Mohammad Shahbazi, Mahmoud Motamedi, Regina Gomes, Ariadne Leal, Carina Verna, Helena Nader, Manuel Simes, Jos Soares, Miriam Varon, Yael Kalma, Ariela Carmon, Tania Cohen, Shiri Tisser, Roni Rahav, Yoni Cohen, Hadar Amir, Ami Amit, Dalit Ben- Yosef, Maria Slomczynska, Katarzyna Knapczyk-Stwora, Malgorzata Grzesiak, Marek Koziorowski, Slawomir Nowak, Trent Newman, Noel Jhinku, Michael Meier, Julia Horsfield, Fatemeh Soheili, Parvin Torabzadeh, Mohammad Atrabi, Ramezan Khanbabaei, Azam Dalman, Mostafa Asl, Mojtaba Valojerdi, Rouhollah Fathi   +38 more
openalex   +1 more source

American Association of Clinical Endocrinologists/American College of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis— 2020 Update Executive Summary [PDF]

, 2020
Pauline M. Camacho, Steven M. Petak, Neil Binkley, Dima L. Diab, Leslie S. Eldeiry, Azeez Farooki, Steven T. Harris, Daniel L. Hurley, Jenny Kelly, E. Michael Lewiecki, Rachel Pessah‐Pollack, Michael R. McClung, Sunil J. Wimalawansa, Nelson B. Watts   +13 more
openalex   +1 more source

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

Bromocriptine approved as the first medication to target dopamine activity to improve glycemic control in patients with type 2 diabetes

Diabetes, Metabolic Syndrome and Obesity, 2010
Michael A Via1, Himani Chandra2, Takako Araki1, Matthew V Potenza3, Maria Skamagas41Division of Endocrinology and Metabolism, Albert Einstein College of Medicine, Beth Israel Medical Center, New York, NY, USA; 2Division of Endocrinology, Diabetes and ...
Via MA
doaj   +2 more sources

Clinical Endocrinology

The Journal of Nervous and Mental disease, 1944
Bibliography at end of most of the chapters. ; Mode of access: Internet.
openaire   +1 more source

Session 69: Clinical endocrinology [PDF]

, 2013
Channa Jayasena, Ali Abbara, Alexander Comninos, Risheka Ratnasabapathy, Johannes D. Veldhuis, Gurjinder Nijher, Zainab Ganiyu‐Dada, A. Mehta, Catriona Todd, M. A. Ghatei, Stephen R. Bloom, Waljit S. Dhillo, Marcin Grynberg, Nelly Frydman, R Frydman, Hellevi Peltoketo, Philippe Bouchard, Rénato Fanchin, Kim Freriks, C.M. Verhaak, Theo Sas, Leonie A. Menke, B.J. Otten, S. M. P. F. d. M. Keizer-Schrama, Jan M. Wit, Romana T. Netea‐Maier, A. R. M. M. Hermus, Roy P. C. Kessels, Henri Timmers, Andrea Busnelli, Laura Benaglia, M. Leonardi, Sonia Faulisi, G. Ragni, Edgardo Somigliana, Sabine Roesner, Bryant A. Toth, Johanna Weigert, Thomas Strowitzki, Markus Montag   +39 more
openalex   +1 more source

An ultra‐processed food‐based cafeteria diet induces obesity, metabolic dysfunction, and tissue‐specific gene dysregulation in C57BL/6 mice

Animal Models and Experimental Medicine, EarlyView.
This schematic figure illustrates the experimental design and key findings of the study. Forty male C57BL/6 mice were assigned to either a standard diet control group or a cafeteria diet (CAFD) group for 16 weeks. CAFD induces obesity, insulin resistance (HOMA‐IR), hepatic steatosis, and dysregulation of a number of genes in visceral and subcutaneous ...
Guilherme Coutinho Kullmann Duarte, Daisy Crispim, Shiva Cerutti Wittée, Joana Raquel Nunes Lemos, Natalia Emerim Lemos, Mayara Souza de Oliveira, Melissa Daniele Alves, Eloísa Toscan Massignam, Tais Silveira Assmann, Felipe Mateus Pellenz   +9 more
wiley   +1 more source