Results 131 to 140 of about 592,446 (323)

Endocrine Entropy

open access: yesJournal of the Pakistan Medical Association
This communication defines and describes the novel concept of endocrine entropy. The authors share insights regarding the various facets of entropy in endocrine epidemiology, physiology, clinical presentation and management.
Sanjay Kalra, Nitin Kapoor
doaj   +1 more source

Metformin enhances external urethral sphincter integrity and restores continence via AMPK activation in a rat model of stress urinary incontinence

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The pathogenesis of stress urinary incontinence (SUI) is intimately associated with injury to the external urethral sphincter (EUS). In this study, we established an SUI model induced by double vaginal distension and demonstrated that metformin treatment activated the AMPK signaling in the EUS tissue.
Yuting Xu   +7 more
wiley   +1 more source

Emergency management of acute adrenal insufficiency (adrenal crisis) in adult patients

open access: yesEndocrine Connections, 2016
Wiebke Arlt   +1 more
doaj   +1 more source

Endocrinology: Patients suffering from H63D syndrome are at high risk to develop clinically relevant endocrine abnormalities affecting their adrenal glands as well as their HPA and SMA axes

open access: green, 2022
Marius Lazar   +16 more
openalex   +2 more sources

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma   +2 more
wiley   +1 more source

Emergency management of acute hypocalcaemia in adult patients

open access: yesEndocrine Connections, 2016
Jeremy Turner   +3 more
doaj   +1 more source

A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis

open access: yesArthritis &Rheumatology, EarlyView.
Objective This study investigated that serum metabolomics, before urate‐lowering therapy (ULT) initiation, could serve as a biomarker for responsiveness to colchicine prophylaxis in patients with gout commencing treat‐to‐target ULT. Methods We studied a multicenter prospective cohort (n = 409) initiating treat‐to‐target ULT plus colchicine prophylaxis.
Wenyan Sun   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy