Results 61 to 70 of about 169,755 (257)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

A survey in Mexico about ethics dumping in clinical research

BMC Medical Ethics, 2019
Background The exportation of unethical practices to low- and middle-income countries (“Ethics Dumping”) has been conceived as a prevalent practice which needs to be examined more closely.
Novoa-Heckel Germán, Bernabe Rosemarie
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Ethics committees and the changed clinical research environment in India in 2016: A perspective!

Perspectives in Clinical Research, 2017
Introduction: Institutional and Independent Ethics Committees (ECs) have as their primary mission the protection of human research subjects. The Central Drugs Standard Control Organization has in the period 2013–2016 introduced several new regulations ...
Sanish Davis, Poonam Sule, Murtuza Bughediwala, Vrunda Pandya, Shilpi Sinha   +4 more
doaj   +1 more source

Hospital ethics committees: Problems in evaluation

, 1992
Hospital ethics committees continue to proliferate, despite the fact that their impact upon practice has not been rigorously evaluated. This paper investigates the reasons why the often recommended evaluation has not yet occurred.
Janet L. Storch, Glenn G. Griener, Griener, Glenn, Griener, Glenn G., Storch, Janet L., Storch, Janet   +5 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Ethical issues in the use of in-depth interviews: literature review and discussion [PDF]

, 2009
This paper reports a literature review on the topic of ethical issues in in-depth interviews. The review returned three types of article: general discussion, issues in particular studies, and studies of interview-based research ethics.
Tod, A., Clarke, Amanda, McDonnell, A., McDonnell, Ann, Allmark, P., Chambers, E., Allmark, Peter, Chambers, Eleni, Tod, Angela Mary, Allmark, P. J., Boote, J., Thompson, A.R., Thompson, Andrew, Clarke, A., Thompson, A., Boote, Jonathan, Tod, Angela   +16 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

The readiness of the Asian research ethics committees in responding to the COVID-19 pandemic: A multi-country survey [version 1; peer review: 2 approved]

F1000Research
Background COVID-19 is a highly challenging infectious disease. Research ethics committees (RECs) have challenges reviewing research on this new pandemic disease under a tight timeline and public pressure.
Asyraf Syahmi Mohd Noor, Kwanchanok Yimtae, Namita Ghimire, Chandanie Wanigatunge, Pradip Gyanwali, Subhanshi Sharma, Harnawan Rizki, Prakash Ghimire, Septi Dewi Rachmawati, Monalisa Waworundeng, Paresh Koli, Lisa Amir, Yashashri Shetty, Sudha Ramalingam, Phanthipha Wongwai, Edlyn B. Jimenez, Cristina E. Torres, Arthur M. Navarro, Juntra Karbwang   +18 more
doaj   +1 more source

Clinical ethics committees

, 2023
Klinisk Etisk Komité (KEK) er et tværfagligt udvalg på et hospital, der har til opgave at analysere etisk udfordrende situationer og belastende valg i forbindelse med patienters diagnose, behandling og prognose [1-3].
Knox, Jeanette Bresson Ladegaard, Rosenberg, Raben   +1 more
core