Results 101 to 110 of about 3,257,610 (298)

A framework for the evaluation of new interventional procedures

, 2012
Objectives: The introduction of new interventional procedures is less regulated than for other health technologies such as pharmaceuticals. Decisions are often taken on evidence of efficacy and short-term safety from small-scale usually observational ...
Vale, Luke, Burr, Jennifer M., Grant, Adrian M., Lourenco, Tania   +3 more
core   +1 more source

A realistic evaluation : the case of protocol-based care [PDF]

, 2010
Background 'Protocol based care' was envisioned by policy makers as a mechanism for delivering on the service improvement agenda in England. Realistic evaluation is an increasingly popular approach, but few published examples exist, particularly in ...
Seers, Kate, Seers Kate, Seers, K., Bick Debra, Bick, Debra, Rycroft-Malone, J., Rycroft-Malone, Jo, Fontenla, M., Bick, D., Fontenla, Maria, Kate Seers, Rycroft-Malone Jo, Fontenla Marina, Jo Rycroft-Malone, Debra Bick, Fontenla, Marina, Marina Fontenla   +16 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Clinical medication review: one step beyond: Computer rules of personal goals?

, 2019
In this ageing society, older persons are using more and more medications for chronic diseases. During a clinical medication review, the community pharmacist evaluate all the medication use together with the patient in a personal conversation.
Verdoorn, Marguerita Alexandra, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology   +2 more
core  

Exploring the Impact of a Clinical Decision Support Tool from the Perspective of Service Users & Carers

, 2008
This study was part of an evaluation of a Clinical Decision Support Tool (CDST) which was developed as the basis for the Integrated Packages Approach to Care (InPac) model for adult mental health services in South West Yorkshire Mental Health NHS Trust ...
Dale, Lesley, Minogue, Virginia, Lucock, Mike, Roberts, Nicola, Glen, Rom, Glen, Ron   +5 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Criteria and regulatory considerations for the conditional approval of innovative antitumor drugs in China: from the perspective of clinical reviewers

Cancer Communications, 2023
Limin Zou, Yueli Qi, Yongling Jiang, Ling Tang, Yu Du, Boyuan Zhao, Yanzhe Sun, Meiyi Xiang, Jun Ma, Zhimin Yang   +9 more
doaj   +1 more source

Tele-therapy based tele-clinical learning in Speech and Hearing Sciences – Evaluation and validation of an evaluation tool

Introduction: Tele-clinical training is an effective approach, increasingly adopted post-pandemic and in resource-limited settings. However, it requires systematic development.
Gayanthi Kodituwakku, Madawa Chandratilake, Bhagya Devagiri, Dinushee Atapattu-Bakmeewewa   +3 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Chinese expert consensus on standardized management of PI3K/AKT inhibitor-associated hyperglycemia in breast cancer (2026 edition)

Zhongguo aizheng zazhi
Breast cancer is the most common malignancy among women in China, with approximately 70% of cases being hormone receptor (HR)-positive. Although current therapeutic strategies have significantly improved patient outcomes, endocrine resistance remains a ...
Clinical Cancer Research Evaluation Committee of Chinese Medical Education Association, Cancer Drug Clinical Research Committee of Shanghai Anti-Cancer Association, Breast Cancer Study Group Along the Yangtze River   +2 more
doaj