Results 121 to 130 of about 3,257,610 (298)

Developing an instrument for evaluating implementation of clinical practice guidelines : a test-retest study

, 2008
Rationale and aims: This study focuses on the development of an instrument for the evaluation of clinical practice guidelines and is one part of a research project about the implementation and use of such guidelines among hospitals in the southern region
Bahtsevani, Christel, Willman, Ania, Östman, Margareta, Khalaf, Azzam   +3 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

AI for evidence-based treatment recommendation in oncology: a blinded evaluation of large language models and agentic workflows

Frontiers in Artificial Intelligence
BackgroundEvidence-based medicine is crucial for clinical decision-making, yet studies suggest that a significant proportion of treatment decisions do not fully incorporate the latest evidence.
Guannan Zhai, Merav Bar, Andrew J. Cowan, Andrew J. Cowan, Samuel Rubinstein, Qian Shi, Ningjie Zhang, En Xie, Will Ma   +8 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Clinical evaluation of detachment and non-detachment of fixed orthodontic appliances fabricated using CAD/CAM technology

Clinical and Investigative Orthodontics
Purpose This study evaluated the bonding characteristics and risk factors for detachment of cobalt-chromium-fixed orthodontic appliances fabricated using computer-aided design/computer-aided manufacturing (CAD/CAM) technology.Materials and methods We ...
Koji Takahashi, So Koizumi, Masatoshi Shimura, Kazuhide Seimiya, Tomotaro Nihei, Tetsutaro Yamaguchi   +5 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

A comparison of clinical paediatric murmur assessment with echocardiography [PDF]

, 2004
Objective: To compare the clinical acumen of paediatric cardiovascular examination between various hospital paediatrician grades. Design: Prospective data collection of clinical and echocardiography findings on paediatric echocardiography referrals ...
Bailey, Mark, Mercieca, Victor, Spiteri, Amaris, Torpiano, John G., Grech, Victor E.   +4 more
core  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

THE CLINICAL EVALUATION OF CHOLANGIOGRAMS

Annals of Surgery, 1948
H, Hagan, H L, Townsend
openaire   +4 more sources