Results 131 to 140 of about 3,257,610 (298)

A comprehensive theoretical framework for the implementation and evaluation of opt-out HIV testing

, 2016
Opt-out HIV testing (in which patients are offered HIV testing as a default) is a potentially powerful strategy for increasing the number of people who know their HIV status and thus limiting viral transmission.
Boldy, Duncan, Leslie, G, Sonya Girdler, Girdler, S,, Girdler, Sonya, Boldy, D, Leidel, Stacy, Gavin Leslie, Duncan Boldy, Leslie, Gavin, Stacy Leidel, Leidel, S   +11 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Clinical Evaluation of amalgam bonded with adhesive resin in primary molars

, 1999
P(論文)This study is evaluatin clinical of amalgam bonded with adhesive resin (4-META/MMATBB) in primary molars. The subjects were 3 to 10 year old 34 children who visited the clinic of a general practitioner in Sapporo.
25672, 畑, 良明
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

International perspective on social cognition in schizophrenia: current stage and the next steps

European Psychiatry
In the last decades, research from cognitive science, clinical psychology, psychiatry, and social neuroscience has provided mounting evidence that several social cognitive abilities are impaired in people with schizophrenia and contribute to functional ...
Silvia Corbera, Matthew M. Kurtz, Amélie M. Achim, Giulia Agostoni, Isabelle Amado, Michal Assaf, Stefano Barlati, Margherita Bechi, Roberto Cavallaro, Satoru Ikezawa, Hiroki Okano, Ryo Okubo, Rafael Penadés, Takashi Uchino, Antonio Vita, Yuji Yamada, Morris D Bell   +16 more
doaj   +1 more source

Evaluating the Effectiveness of Alcohol and Substance Abuse Services for American Indian/Alaska Native Women

, 2014
The major goal of Phase II of this study was to collect and analyze much-needed descriptive, demographic, social, cultural, and clinical information about women receiving treatment in alcohol and substance abuse treatment centers funded in whole or in ...
University of California, San Francisco, Institute for Health Policy Studies, San Francisco, CA.
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The feasibility of diagnosing sprained ankle via 3D MRI reconstructing three-dimensional model of anterior talofibular ligament

Frontiers in Sports and Active Living
IntroductionThe anterior talofibular ligament (ATFL) is the most vulnerable ligament in ankle sprains. Most patients recover after this injury with conservative treatment, while 20%—40% progress to chronic ankle instability that requires surgical ...
Lei He, Lei He, Meng Dai, Meng Dai, Yan Xu, Liu Ouyang, Deyu Duan, Zhaogang Huang, Chenghao Xiang, Chenghao Xiang   +9 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Clinical utility of exome sequencing in hearing loss: a retrospective cohort study

Frontiers in Genetics
BackgroundHearing loss (HL) is a prevalent sensorineural disorder with a highly heterogeneous etiology. Next-generation sequencing (NGS) has revolutionized the genetic testing landscape for diseases characterized by high genetic and allelic heterogeneity,
Chang Liu, Chang Liu, Yanlin Huang, Yanlin Huang, Anpeng Fu, Anpeng Fu, Yunan Wang, Yunan Wang, Jing Wu, Jing Wu, Yan Zhang, Yan Zhang, Li Du, Li Du, Hongke Ding, Hongke Ding, Lihua Yu, Lihua Yu, Fake Li, Fake Li, Yiming Qi, Yiming Qi, Yuan Liu, Yuan Liu, Xingwang Wang, Xingwang Wang, Yukun Zeng, Yukun Zeng, Ling Liu, Ling Liu, Ying Xiong, Ying Xiong, Yuanling Liu, Yuanling Liu, Xin Zhao, Xin Zhao, Liyuan Fang, Liyuan Fang, Jiayi Jian, Jiayi Jian, Aihua Yin, Aihua Yin, Yanqin You   +42 more
doaj   +1 more source