Results 171 to 180 of about 3,257,610 (298)

Prospective blinded clinical evaluation of a fully automated workflow for prostate radiotherapy. [PDF]

Phys Imaging Radiat Oncol
Neugebauer D, Bolten JH, Lau HH, Mende S, Rackwitz T, Held T, Grott C, Rademacher J, Weykamp F, Meixner E, Hoegen-Sassmannshausen P, Debus J, Klüter S, Liermann J.   +13 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Ventricular Repolarization Abnormalities in Pediatric Athletes: A Practical Approach to Clinical Evaluation. [PDF]

J Cardiovasc Dev Dis
Morra L, Borzuola R, Gianfelici A, Nifosì F, Quaranta F, Calò L, Pigozzi F, Fossati C.   +7 more
europepmc   +1 more source

Review of mini-clinical evaluation exercise (mini-CEX) in a psychiatry clerkship

, 2018
Edwin Meresh,1 David Daniels,2 Aparna Sharma,1 Murali Rao,1 Kaushal Mehta,3 David Schilling1 1Department of Psychiatry and Behavioral Neurosciences, Stritch School of Medicine, Loyola University Medical Center, Maywood, IL, USA; 2Department of Psychiatry,
Mehta K, Sharma A, Daniels D, Meresh E, Schilling D, Rao M   +5 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Anti‐tumor drug supervision in China from 2010 to 2024: the evolution and prospect of drug review standards

Cancer Communications
Ling Tang, Yuanyuan Song, Hong Zhang, Ruimin Hao, Xin Tong, Xing Ai, Jun Ma, Zhimin Yang   +7 more
doaj   +1 more source

Commentary: Clinical evaluation of pediatric olfactory disorders: a review from etiology to management. [PDF]

Front Allergy
Spencer GM, Bhargava EK.
europepmc   +1 more source

Non-Clinical Safety Evaluation of Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells in Cynomolgus Monkeys

Xin-Mei Hu,1,* Can-Can Wang,1,* Yu Xiao,1 Yu Liu,1 Hong-Ri Huang,2 Peng Jiang,1 Ying-Kai Wang,1 Yun-Jin Lin,1 Liang-Cheng Li,3 Zhong-Quan Qi1 1Medical College, Guangxi University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of ...
Liu Y, Hu XM, Li LC, Xiao Y, Lin YJ, Qi ZQ, Wang CC, Huang HR, Wang YK, Jiang P   +9 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Clinical Evaluation of a Polyethylene Glycol Derivative Rinse for Xerostomia. [PDF]

Dent J (Basel)
Singh ML, Davis B, Bairos T, Cimmino J, Singh I, Ahn M, Nho K.   +6 more
europepmc   +1 more source