Results 201 to 210 of about 2,881,753 (249)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Design improvements and clinical evaluation of an adjustable clubfoot splint. [PDF]

Sci Rep
Beldar MK, Ahuja BB, Chougule NK, Sahoo K, Mohite DD.   +4 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Clinical evaluation of airway stent implantation in the treatment of airway stenosis: A systematic review and meta-analysis. [PDF]

Medicine (Baltimore)
Hua M, Li L, Du X, Fu Z, Zhang J.
europepmc   +1 more source

An initial clinical evaluation of quantitative susceptibility mapping for quantitative characterization of intramyocardial hemorrhage. [PDF]

J Cardiovasc Magn Reson
Tyler A, Li Kam Wa ME, Littlewood SJ, Huang L, Bosio F, Chiribiri A, Benedetti G, Roujol S, Masci PG.   +8 more
europepmc   +1 more source

Clinical evaluation of children referred to paediatric haematology clinics for elevated serum vitamin B₁₂ levels. [PDF]

BMJ Paediatr Open
Yiğit Y.
europepmc   +1 more source

The BPPV-SQ: Development and Clinical Evaluation of a Brief Screening Questionnaire for Benign Paroxysmal Positional Vertigo. [PDF]

Audiol Res
Asprella-Libonati G, Asprella-Libonati F, Familiari M, Rizzi V, Gallipoli C, Laguardia M, Gagliardi G, Guida A, Lapacciana G, Colella L, Cavallaro G.   +10 more
europepmc   +1 more source

Clinical Evaluation of Pharmacokinetics, Efficacy, and Safety of a 10% Immunoglobulin in Primary Immunodeficiency Disease (CARES10 Study). [PDF]

Adv Ther
Roifman CM, McNeil D, Lumry W, Wasserman RL, Kanarek H, Moy J, Zecca T, Rehman SM, Raasch J, Lehman H, Norton M, Calcinai M, Kleyn A, Perez E, CARES10 Investigator Working Group.   +14 more
europepmc   +1 more source

Clinical evaluation of laparoscopic repair with quadruple therapy for acute gastric ulcer perforation in elderly patients. [PDF]

Front Pharmacol
Zhai P, Xu DC, Guo YH, Zhang HG.
europepmc   +1 more source