Results 161 to 170 of about 636,139 (316)

The detection, assessment and clinical evolution of interstitial lung abnormalities identified through lung cancer screening. [PDF]

ERJ Open Res, 2023
Balata H, Punjabi A, Chaudhuri N, Greaves M, Yorke J, Booton R, Crosbie P, Hayton C.   +7 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Association between diagnosis, clinical outcome and hospitalization time of the elderly in a university hospital

O Mundo da Saúde, 2019
Clinical outcomes of hospitalized elderly provide subsidies to prevent complications that interfere with quality of life. Objectives: to verify the sociodemographic characteristics and to analyze the associations between the diseases diagnosed at ...
Alexandre Lins Werneck, Camilla Christina Rodrigues, Cláudia Bernardi Cesarino, Nadia Antonia Aparecida Poletti, Rita de Cássia Helú Mendonça Ribeiro, Renato Mendonça Ribeiro, Silvia Maria Albertini   +6 more
doaj  

Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone. [PDF]

World Allergy Organ J, 2022
Sánchez J, Álvarez L, Cardona R.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Lepra lepromatosa: presentación de caso

Revista Médica Electrónica
La lepra es una enfermedad crónica transmisible tan antigua como el hombre mismo. La Organización Mundial de la Salud ha desarrollado un programa orientado a prevenir, diagnosticar oportunamente y tratar de forma adecuada.
Naylis Martínez Collado, Caridad Valle Sánchez, Kaydi Sánchez Hernández   +2 more
doaj  

Clinical Evolution and Risk Factors in Patients Infected during the First Wave of COVID-19: A Two-Year Longitudinal Study. [PDF]

Trop Med Infect Dis, 2023
Rescalvo-Casas C, Pérez-Tanoira R, Villegas RF, Hernando-Gozalo M, Seijas-Pereda L, Pérez-García F, Moríñigo HM, Gómez-Herruz P, Arroyo T, González R, Expósito CV, Lledó García L, Cabrera JR, Cuadros-González J.   +13 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The Onset of Creutzfeldt-Jakob Disease After COVID-19: Navigating the Diagnostic Challenges and Clinical Evolution. [PDF]

Case Rep Neurol Med
Burakgazi AZ.
europepmc   +1 more source