Results 181 to 190 of about 636,139 (316)

Correction to: Evaluation of the clinical evolution and transmission of SARS-CoV-2 infection in cats by simulating natural routes of infection. [PDF]

Vet Res Commun, 2023
Barroso-Arevalo S, Sanchez-Morales L, Barasona JA, Rivera B, Sánchez R, Risalde MA, Agullo-Ros I, Sanchez-Vizcaino JM.   +7 more
europepmc   +1 more source

Diversity in Adaptive Evolution of Methicillin-Resistant Staphylococcus aureus Clinical Isolates Under Exposure to Continuous Linezolid Stress in vitro

Tala Han,1 Ting Jia,1 Junrui Wang1,2 1Department of Laboratory Medicine, Affiliated Hospital of Inner Mongolian Medical University, Hohhot, 010050, People’s Republic of China; 2Inner Mongolia Key Laboratory of Clinical Pathogenic Microorganism, The ...
Jia T, Han T, Wang J
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Pharmacogenetics association with long-term clinical evolution in a kidney transplant patients cohort. [PDF]

Curr Res Pharmacol Drug Discov
Sendra L, Olivera-Pasquini GG, Zucchet EG, Genvigir FDV, Beneyto MI, Hernández-Jaras J, Herrero MJ, Aliño SF.   +7 more
europepmc   +1 more source

Role of epigenetics in the clinical evolution of COVID-19 disease. Epigenome-wide association study identifies markers of severe outcome. [PDF]

Eur J Med Res, 2023
Calzari L, Zanotti L, Inglese E, Scaglione F, Cavagnola R, Ranucci F, Di Blasio AM, Stefanini G, Carlo G, Parati G, Gentilini D.   +10 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Corrigendum to "Pharmacogenetics association with long-term clinical evolution in a kidney transplant patients cohort" [Curr. Res. Pharmacol. Drug Discov. 9 (2025) 100230]. [PDF]

Curr Res Pharmacol Drug Discov
Sendra L, Olivera-Pasquini GG, Zucchet EG, Genvigir FDV, Beneyto MI, Hernández-Jaras J, Herrero MJ, Aliño SF.   +7 more
europepmc   +1 more source

Clinical evolution of HCV-related chronic hepatitis

, 1995
Evolution of HCV positive chronic hepatitis to cirrhosis has been reported to occur in about 30% of patients after five years of follow-up. In contrast, evolution of cirrhosis to decompensation and liver failure is slow, with a survival rate at 5 and 10 ...
Mura D, Dore MP, Realdi G, Giustina G, FATTOVICH, Giovanna   +4 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Clinical Evolution of Neuropsychiatric Symptoms in Alzheimer's Disease and Dementia With Lewy Bodies in a Post-Mortem Cohort. [PDF]

Int J Geriatr Psychiatry
Gibson LL, Skogseth RE, Hortobagyi T, Vik-Mo AO, Ballard C, Aarsland D.   +5 more
europepmc   +1 more source