Results 31 to 40 of about 636,139 (316)

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Clinical Evolution of the Invisalign Appliance

Journal of the California Dental Association, 2002
The Invisalign System of tooth movement has been available to orthodontists since 1999 and has now become available to the entire dental profession. This paper explores the role of this system within the dental armamentarium and describes the clinical evolution of the appliance, based on a feasibility study initiated at the University of the Pacific in
Vicki, Vlaskalic, Robert L, Boyd
openaire   +2 more sources

Initial mutations direct alternative pathways of protein evolution

, 2011
Whether evolution is erratic due to random historical details, or is repeatedly directed along similar paths by certain constraints, remains unclear. Epistasis (i.e.
J Arjan G M de Visser, Tawfik Dan S., Salverda, M.L.M., Merijn L M Salverda, Hoekstra, R.F., Salverda Merijn L. M., Dellus, E., John van der Oost, Alfons J M Debets, Visser, J.A.G.M., de, Gorter Florien A., de Visser J. Arjan G. M., Florien A Gorter, Dellus Eynat, Dan S Tawfik, Gorter, F.A., Debets Alfons J. M., van der Oost John, Eynat Dellus, Hoekstra Rolf F., Debets, A.J.M., Oost, J., van der, J. Arjan G. M. de Visser, Merijn L. M. Salverda, Tawfik, D.S., Florien A. Gorter, Alfons J. M. Debets, Rolf F Hoekstra, de Visser, J.A.G.M., van der Oost, J., Rolf F. Hoekstra, Dan S. Tawfik   +31 more
core   +1 more source

The science of clinical practice: disease diagnosis or patient prognosis? Evidence about "what is likely to happen" should shape clinical practice. [PDF]

, 2015
BACKGROUND: Diagnosis is the traditional basis for decision-making in clinical practice. Evidence is often lacking about future benefits and harms of these decisions for patients diagnosed with and without disease.
Peat, George, Steffen E Petersen, Douglas G Altman, Perel, P, Petersen, SE, Deeks, Jonathan J, Peter Croft, Van Der Windt, Danielle A, Richard D Riley, Hay, AD, Peat, G, Croft, Peter, Altman, DG, Van Der Windt, DA, Richard J Stevens, Harry Hemingway, Riley, Richard D; id_orcid, Michael Sharpe, LeResche, Linda, Linda LeResche, Roberts, Ian, George Peat, Croft, P, Kate M Dunn, Hemingway, Harry, Altman, Douglas G, Stevens, Richard J, Stevens, RJ, Jonathan J Deeks, Dunn, Kate M, Deeks, JJ, Sharpe, M, Adam Timmis, LeResche, L, Timmis, A, Hay, Alastair D, Von Korff, M, Sharpe, Michael, Dunn, KM, Michael Von Korff, Perel, Pablo, Riley, RD, Ian Roberts, Von Korff, Michael, Alastair D Hay, Pablo Perel, Petersen, Steffen E, Riley, Richard D, Danielle A Van Der Windt, Timmis, Adam, Hemingway, H, Roberts, I   +51 more
core   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Influência da gestação na evolução clínica materno-fetal de portadoras de cardiomiopatia hipertrófica Influence of pregnancy on clinical course and fetal outcome of women with hypertrophic cardiomyopathy

Arquivos Brasileiros de Cardiologia, 2007
OBJETIVOS: Estudar a evolução clínica de gestantes com CMH, a influência da gestação sobre o curso natural da CMH e a freqüência da doença nos filhos dessas mulheres no início da infância.
Walkiria Samuel Avila, Florence M. Cavalcanti Amaral, Jose Antonio Franchini Ramires, Eduardo Giusti Rossi, Max Grinberg, Maria Rita Lemos Bortolotto, Charles Mady, José Eduardo Krieger, Marcelo Zugaib   +8 more
doaj   +1 more source

Clinical trial designs for evaluating and exploiting cancer evolution

, 2023
The evolution of drug-resistant cell subpopulations causes cancer treatment failure. Current preclinical evidence shows that it is possible to model herding of clonal evolution and collateral sensitivity where an initial treatment could favourably ...
Porta, N, Graham, TA, Nuria Porta, Banerji, U, Ingles Garces, AH, Alvaro H. Ingles Garces, Udai Banerji, Trevor A. Graham   +7 more
core   +1 more source

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source

Complicaciones de los tubos de tórax Complications of tube thoracostomy

Revista Colombiana de Cirugía, 2009
El drenaje del espacio pleural es una frecuente práctica clínica de valor diagnóstico y terapéutico. Las indicaciones más frecuentes de este procedimiento tienen que ver con situaciones en las que se producen depósitos de fluidos en esta cavidad, como ...
Leonidas Tapias, Luis Felipe Tapias-Vargas, Leonidas Tapias-Vargas   +2 more
doaj  

Natural abundance isotope ratios to differentiate sources of carbon used during tumor growth in vivo

BMC Biology, 2021
Background Radioactive or stable isotopic labeling of metabolites is a strategy that is routinely used to map the cellular fate of a selected labeled metabolite after it is added to cell culture or to the circulation of an animal.
Petter Holland, William M. Hagopian, A. Hope Jahren, Tor Erik Rusten   +3 more
doaj   +1 more source