Results 101 to 110 of about 8,692,801 (257)

HSE National Centre for Clinical Audit Clinical Audit – A Practical Guide

, 2023
This document replaces the previously published “A Practical Guide to Clinical Audit” (HSE 2013). It forms part of a series of resources being developed to support services and all healthcare professionals to ensure the continuation and development of ...
HSE National Centre for Clinical Audit
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Retrospective Evaluation of Synovial Chondromatosis with Histopathological and Clinical Features [PDF]

Objective: Synovial chondromatosis (SC) is a rare, benign condition characterized by the formation of nodular cartilage within the synovium of joints, bursae, or tendon sheaths.
Özden ÖZ, Gülçin BAŞDEMİR, Murat SEZAK, Hüseyin KAYA, Elcil KAYA BİÇER, Emin BÜYÜKTALANCI, İpek TAMSEL, Başak DOĞANAVŞARGİL   +7 more
core   +1 more source

HIV/AIDS clinical manifestations and their implication for patient clinical staging in resource limited settings in Tanzania [PDF]

, 2011
BACKGROUND: Tanzania HIV/AIDS management follows WHO clinical staging which requires CD4 counts as complement. Lacking CD4 counts facilities in rural health facilities remains a challenge. Simplified and sensitive clinical staging based on local clinical
Mugusi, F., Rumisha, S. F., Tanner, M., Omari, Minzi, Marcel, Tanner, Omari, M., Idindili, B., Susan Fred, Rumisha, Ferdinand, Mugusi, Idindili Boniphace, Minzi, O., Boniphace, Idindili, Rumisha, S.F.   +12 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Problematic clinical features of powered wheelchair users with severely disabling multiple sclerosis [PDF]

, 2014
This article is made available through the Brunel Open Access Publishing Fund. Copyright @ 2014 Informa UK Ltd.Purpose: The aim of this study is to describe the clinical features of powered wheelchair users with severely disabling multiple sclerosis (MS)
Frank, AO, Desouza, LH, De Souza, LH
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Analysis of clinical-imaging-pathological features and preoperative misdiagnosis status of 47 cases of gastric schwannomas: a single-center retrospective study over 13 years

World Journal of Surgical Oncology
Objective To identify the diagnostic difficulties of gastric schwannomas (GS) and provide evidence for improving the accuracy of clinical diagnosis. Methods A retrospective analysis was conducted on the data of 47 patients with pathologically confirmed ...
Xiaoxiao Ruan, Ruijiao Zhu, Wei Wang, Daorong Wang, Bin Liu   +4 more
doaj   +1 more source

The Pharmacological Management of Cancer Pain in Adults Clinical Audit Tool

, 2016
The audit standards are based on the Pharmacological Management of Cancer Pain in Adults NCEC National Clinical Guideline No. 9. In developing this tool consideration has been given to the clinical issues covered by the guideline and the potential ...
National Clinical Programme for Palliative Care
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