Results 111 to 120 of about 8,692,801 (257)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Takayasu's arteritis in Turkey - clinical and angiographic features of 248 patients

, 2009
Objective. Takayasu's arteritis (TA) is a chronic, inflammatory vasculitis affecting the aorta and its major branches. Although it is more, prevalent in Far-East Asia, the distribution of the disease is worldwide with different vascular involvement ...

core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Most Common Dermatological Findings In Atopic Dermatitis

Diyala Journal of Medicine, 2018
Background: Atopic dermatitis (AD) is a common, chronic, relapsing, itchy, skin condition occurring in patients with a personal or family history of atopy. It varies widely in clinical presentation at different ages and places.
Hasan Nasir AL-Musawi
doaj   +2 more sources

Epidemiology and Clinical Features of Mpox in Jakarta, Indonesia, August 2022–December 2023

Vaccines
Background/Objective: This study explores the epidemiology and clinical features of re-emerging mpox in Jakarta, Indonesia. Methods: This study used a retrospective study design to describe the epidemiological data, clinical features, and mortality of ...
Hanny Nilasari, Eliza Miranda, Melani Marissa, Ani Ruspitawati, Dwi O. T. L. Handayani, Ngabila Salama, Budi Setiawan, Supriadi, Tiranti V. Aisyah, Inggariwati, Arif S. Haq, Siti Zuhroh, Eka Y. Safitri, Rahmat A. Pramono, Inggrita Wisnuwardani, Erni J. Nelwan, Robert Sinto, Adityo Susilo, Yulia R. Saharman, Suratno L. Ratnoglik, Ni L. P. Pitawati, Muhammad Fauzan, Sekar S. A. Hasanah, Megandhita Sharasti, Evy Yunihastuti   +24 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Clinical and laboratory features in different immunologic type of multiple myeloma [PDF]

Medicinski Podmladak, 2018
Introduction: Multiple myeloma (MM) is a malignant blood disease, characterized by clonal proliferation of malignant plasma cells in the bone marrow and clinical manifestation of a disease that is heterogeneous and it's stratified by an internationally ...
Stojković Mina, Mladenović Adrijana, Spasić Marija, Govedarović Nenad   +3 more
doaj  

Clinical features and neuroimaging of PARK7-linked parkinsonism.

, 2003
Item does not contain fulltextWe recently reported linkage to chromosome 1p36 (the PARK7-locus) in a family with early-onset parkinsonism. Linkage to this locus has since been confirmed in an independent data set.
Oostra, B.A., Heutink, P., van Swieten, J.C., Leenders, N., Galjaard, Robert-Jan, Horstink, M.W.I.M., Galjaard, R J, van Swieten, J, Galjaard, RJ, Oostra, Ben, Heutink, P, Dekker, MCJ (Marieke), Bonifati, Vincenzo, Bonifati, [No Value], Oostra, B, Bonifati, V, Duijn, C.M. van, Dekker, M, Swieten, J. van, van Duijn, C, Horstink, M, Leenders, N, Snijders, P.J.L.M., Duijn, Cornelia, Bonifati, V., Dekker, M.C.J., Galjaard, R.J.   +26 more
core   +1 more source