Results 141 to 150 of about 21,937,235 (349)

Characteristics of Mid-Frequency Sensorineural Hearing Loss Progression. [PDF]

, 2019
OBJECTIVES:To characterize the progression of mid-frequency sensorineural hearing loss (MFSNHL) over time. METHODS:A retrospective chart review spanning 2012 to 2017 was performed at a tertiary care audiology and neurotology center.
Abouzari, Mehdi, Birkenbeuel, Jack, Cheung, Dillon, Djalilian, Hamid R, Gelnett, Donna, Goshtasbi, Khodayar, Lin, Harrison W, Moshtaghi, Afsheen, Moshtaghi, Omid, Sahyouni, Ronald   +9 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Pulmonary and renal long COVID at two-year revisit

iScience
Summary: This study investigated host responses to long COVID by following up with 89 of the original 144 cohorts for 1-year (N = 73) and 2-year visits (N = 57).
Jing Wang, Xiao Liang, Yufen Zheng, Yi Zhu, Kai Zhou, Xiaomai Wu, Rui Sun, Yifan Hu, Xiaoli Zhu, Hongbo Chi, Shanjun Chen, Mengge Lyu, Yuting Xie, Xiao Yi, Wei Liu, Xue Cai, Sainan Li, Qiushi Zhang, Chunlong Wu, Yingqiu Shi, Donglian Wang, Minfei Peng, Ying Zhang, Huafen Liu, Chao Zhang, Sheng Quan, Ziqing Kong, Zhouyang Kang, Guangjun Zhu, Hongguo Zhu, Shiyong Chen, Junbo Liang, Hai Yang, Jianxin Pang, Yicheng Fang, Haixiao Chen, Jun Li, Jiaqin Xu, Tiannan Guo, Bo Shen   +39 more
doaj   +1 more source

Catatonia in Hospitalized Patients With COVID-19: An Important Clinical Finding That Should Not be Missed. [PDF]

J Mov Disord, 2022
Ong TL, Sapuan S.
europepmc   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Persistent Facial Flushing in a Patient with Telangiectasia Macularis Eruptiva Perstans: An Unusual but Should Emphasized Clinical Finding. [PDF]

Clin Cosmet Investig Dermatol, 2022
He X, Wang B, Jia X, Li Y, Yan H, Mu Q, Chen S.   +6 more
europepmc   +1 more source

NICEly does it: economic analysis within evidence-based clinical practice guidelines [PDF]

There is increasing professional and policy interest in the role of clinical guidelines for promoting effective and efficient health care. The NHS Health Technology Assessment Programme identified an urgent need, when such guidelines are produced, to ...
James Mason, Martin Eccles, Mike Drummond, Nick Freemantle   +3 more
core  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Laparoscopic surgery for a hydrocele of the canal of Nuck with an ovarian tumor: An extremely rare clinical finding. [PDF]

Clin Case Rep, 2022
Tominaga M, Morikawa K, Ogawa Y, Kamimura N, Tsuneki I, Tamura M, Yanase T, Kobayashi K, Sato D, Kameyama H, Iwaya A, Yokoyama N, Kuwabara S, Yamazaki T, Otani T, Kurabayashi T.   +15 more
europepmc   +1 more source