FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Finding the K shortest hyperpaths using reoptimization [PDF]
The shortest hyperpath problem is an extension of the classical shortest path problem and has applications in many different areas. Recently, algorithms for finding the K shortest hyperpaths in a directed hypergraph have been developed by Andersen ...
Andersen, Kim Allan +2 more
core
Data-Driven Prior Distributions for A Bayesian Phase-2 COPD Dose-Finding Clinical Trial
, 2018 The prior distribution reflects knowledge and uncertainty of the modeled parameters. Determining the prior distribution for a dose-finding clinical trial can be influential in its design and analysis. Using the planning of a phase 2 trial for COPD with a
Shuyen Ho (5154455) +2 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Cough hypersensitivity in patients with metabolic syndrome: a clinical finding and its possible mechanisms. [PDF]
BMC Pulm Med, 2021 Cheng J +7 more
europepmc +1 more source
Dose selection in seamless phase II/III clinical trials based on efficacy and toxicity [PDF]
Seamless phase II/III clinical trials are attractive in development of new drugs because they accelerate the drug development process. Seamless phase II/III trials are carried out in two stages.
Kimani, Peter K.
core
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Keratotic spines in a patient with pruritic and dyskeratotic dermatosis: A new clinical finding. [PDF]
JAAD Case Rep, 2021 Kwan K +7 more
europepmc +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Aging in Cats: Owner Observations and Clinical Finding in 206 Mature Cats at Enrolment to the Cat Prospective Aging and Welfare Study. [PDF]
Front Vet Sci, 2022 Dowgray N +5 more
europepmc +1 more source