Results 101 to 110 of about 7,785,903 (293)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Exploring the Genetic Architecture of Myocarditis and Inherited Cardiomyopathies

Cardiogenetics
Myocarditis is a complex inflammatory myocardial disease. Although traditionally regarded as exclusively immune-mediated, recent evidence highlights the significant role of underlying genetics on susceptibility, phenotypic variability, and long-term ...
Sukruth Pradeep Kundur, Ali Malik, Rasi Mizori, Sanjay Sivalokanathan   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

FFT-GA-BC: a fused federated transformer genetic algorithm framework with blockchain-secured, differentially private, homomorphically encrypted aggregation for mutation, phenotype, and binary-allele analysis

Frontiers in Medicine
Federated learning enables cross-institutional clinical-genetics analytics without sharing raw patient data; yet, no existing framework integrates the full cryptographic stack–differential privacy, homomorphic encryption, and blockchain auditing—required
Muhammad Umar Nasir, Muhammad Umar Nasir, Muhammad Umar Nasir, Muhammad Umar Nasir, Urva Rehmat, Abdul Khader Jilani Saudagar, Mona Alkhattabi, Muhammad Adnan Khan, Muhammad Amir Khan   +8 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Population Genetics [PDF]

, 2006
Population genetics attempts to measure the influence of the causes of evolution, viz., mutation, migration, natural selection, and random genetic drift, by understanding the way those causes change the genetics of populations. But how does it accomplish
Millstein, Roberta L., Skipper, Robert A.   +1 more
core  

Training in clinical genetics and genetic counseling in Asia

, 2019
The status of training in clinical genetics and genetic counseling in Asia is at diverse stages of development and maturity. Most of the training programs are in academic training centers where exposure to patients in the clinics or in the hospital is a ...
Lai, PS, Sura, T, Thong, MK, Cutiongco-de La Paz, EM, Chen, YH, Faradz, SMH, Laurino, M, Lin, SP, Chung, BHY, David-Padilla, C   +9 more
core   +1 more source

A review on clinical genetics in Bovidae

, 2016
A review on clinical genetics in Bovidae .
Capitan, Aurelien
core   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

GENETICS AND INSURANCE

, 1999
Contributors -- Abbreviations -- Preface -- Ch. 1. Insurance, genetics and solidarity / J. Husted -- Ch. 2. Genetics, insurance and risk / F. Ewald -- Ch. 3. Genetic discrimination / V. Launis - - Ch. 4.

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