Results 81 to 90 of about 6,319,608 (297)

Genetics and public health [PDF]

, 2005
Educational Items on Genetics and public ...
Laberge, AM
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Deciphering mechanisms leading to preterm birth through post-GWAS integration of multi-omics data

iScience
Summary: Preterm birth (birth before 37 weeks) is a major cause of neonatal mortality and is linked to various health adversities in childhood and adult life. This study investigates the genetic factors contributing to spontaneous preterm birth (sPTB) in
Esha Bhattacharjee, Ramachandran Thiruvengadam, Divyank Varshney, Jagyashila Das, Ayushi, Rishika Maji, Piyali Mondal, Supratim Ghosh, Pragya Tailor, Uma Chandra Mouli Natchu, Nitya Wadhwa, Pallavi Kshetrapal, Shinjini Bhatnagar, Arindam Maitra   +13 more
doaj   +1 more source

Genetics and genomic medicine in Sri Lanka

Molecular Genetics & Genomic Medicine, 2019
The completion of the Human Genome Project in 2003 heralded in a new era marked by remarkable advances in biomedical research leading to the establishment of genomics‐based translational medicine mainly in the developed world. However, the development of
Nirmala D. Sirisena, Vajira H. W. Dissanayake   +1 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The challenges and opportunities of offering and integrating training in clinical molecular genetics and clinical cytogenetics: A survey of LGG Fellowship Program Directors [PDF]

Purpose: The specialty of Laboratory Genetics and Genomics (LGG) was created in 2017 in an effort to reflect the increasing convergence in technologies and approaches between clinical molecular genetics and clinical cytogenetics.
Elena A. Repnikova, Vance, Gail, Yang Cao, Del Gaudio, Daniela, Luo, Minjie, Booker, Jessica, Shao, Lina, Teresa A. Smolarek, Deignan, Joshua L., Williams, Eli, Repnikova, Elena, Jessica K. Booker, Repnikova, Elena A., Vnencak-Jones, Cindy L, Li, Shibo, Rizwan C. Naeem, Leung, Marco L., Van Ziffle, Jessica, Hufnagel, Robert B, Gail H. Vance, Vimla Aggarwal, Deak, Kristen L., Pollard, Laura M, Naeem, Rizwan C, Bellissimo, Daniel B, Williams, Eli S, Deak, Kristen, Hufnagel, Robert B., Smolarek, Teresa, Hufnagel, Robert, Shaw, Brandon, Minjie Luo, Hoppman, Nicole L, Cindy L. Vnencak-Jones, Hoppman, Nicole, Daniela Del Gaudio, Cao, Yang, Liu, Pengfei, Stephen R. Moore, Moore, Stephen R., Leung, Marco L, Funke, Birgit, Colleen Jackson-Cook, Vanessa Horner, Mason-Suares, Heather, Moore, Stephen, Shaw, Brandon M, Shibo Li, Kristy R. Crooks, Naeem, Rizwan, Mao, Minjie Luo Rong, Lina Shao, Mikhail, Fady, Vance, Gail H., Vnencak-Jones, Cindy, Pollard, Laura, Heather Mason-Suares, Bale, Allen E., Bellissimo, Daniel B., Kristen L. Deak, Laura M. Pollard, Birgit Funke, Bellissimo, Daniel, Fady M. Mikhail, Elizabeth Spiteri, Daniel B. Bellissimo, Rong Mao, Spiteri, Elizabeth, Koduru, Prasad, Deignan, Joshua, Brandon M. Shaw, Shaw, Brandon M., Eli S. Williams, Repnikova, Elena A, Bale, Allen, Vnencak-Jones, Cindy L., Allen E. Bale, Vance, Gail H, Leung, Marco, Prasad Koduru, Booker, Jessica K, Jessica Van Ziffle, Crooks, Kristy R., Pengfei Liu, Crooks, Kristy R, Marco L. Leung, Jackson-Cook, Colleen, Mikhail, Fady M., Bale, Allen E, Robert B. Hufnagel, Aggarwal, Vimla, Joshua L. Deignan, Mikhail, Fady M, Deak, Kristen L, Nicole L. Hoppman, Smolarek, Teresa A, Booker, Jessica K., Moore, Stephen R, Deignan, Joshua L, Pollard, Laura M., Williams, Eli S., Crooks, Kristy, Smolarek, Teresa A., Shashirekha Shetty, Hoppman, Nicole L., Shetty, Shashirekha, Horner, Vanessa, Naeem, Rizwan C., Mao, Rong   +108 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Case report: Unveiling genetic and phenotypic variability in Nonketotic hyperglycinemia: an atypical early onset case associated with a novel GLRX5 variant

Frontiers in Genetics
Nonketotic hyperglycinemia (NKH) is a rare, autosomal recessive metabolic disorder usually associated with mutations in genes AMT, GLDC or GCSH involved in the glycine cleavage complex.
Victor Marin, Louis Lebreton, Claire Guibet, Claire Guibet, Samir Mesli, Isabelle Redonnet-Vernhet, Mathurin Dexant, Delphine Lamireau, Sandrine Roche, Margaux Gaschignard, Jean Delmas, Henri Margot, Claire Bar   +12 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source