Results 151 to 160 of about 6,319,608 (297)

Clinical genetics

, 2000
http://dx.doi.org/10.1136/bmj.287.6398 ...
Burn, John
core  

Jervell and Lange-Nielsen Syndrome Related Clinical Genetics and Experimental Models. [PDF]

Pediatr Discov
Zhou Y, Huang CL, Yang Y, Zhang Y.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Clinical genetics [PDF]

BMJ, 2001
J. P. van Tintelen, C. Marcelis, I. M. van Langen   +2 more
  +4 more sources

Clinical genetics: past, present and future. [PDF]

Eur J Hum Genet, 2022
Tromans E, Barwell J.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A comprehensive approach to users from a Brazilian clinical genetics service: an observational study. [PDF]

Orphanet J Rare Dis
de Francisco DD, Silva IMW, Steiner CE, Gil-da-Silva-Lopes VL.   +3 more
europepmc   +1 more source

Underrepresentation of the term cerebral palsy in clinical genetics databases. [PDF]

Am J Med Genet A, 2022
Srivastava S, Lewis SA, Kruer MC, Poduri A.   +3 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Review Article: Overview of Clinical Genetics of Diabetes Mellitus. [PDF]

Genes (Basel)
Asamoah A, Ahima RS.
europepmc   +1 more source