Results 201 to 210 of about 1,217,808 (321)

Clinical practice guidelines for the management of atypical haemolytic uraemic syndrome in the United Kingdom [PDF]

, 2010
,, Goodship, Tim H J, Machin, Sam, Taylor, C Mark, Wigmore, Stephen J   +4 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Addressing Cross-Specialty Clinical Genetics Education Needs. [PDF]

J Contin Educ Health Prof
Lindquist KJ, Ryan MJ, Scheuner MT, Tamraz B, Flowers E, Harris-Wai J, Biswas S, Hyland K.   +7 more
europepmc   +1 more source

Clinical genetics in transition-a comparison of genetic services in Estonia, Finland, and the Netherlands. [PDF]

J Community Genet, 2021
Vrijenhoek T, Tonisson N, Kääriäinen H, Leitsalu L, Rigter T.   +4 more
europepmc   +1 more source

Recent developments in genetics and medically-assisted reproduction: from research to clinical applications†‡ [PDF]

, 2017
Joyce Harper, Kristiina Aittomäki, Pascal Borry, Martina C. Cornel, Guido de Wert, Wybo Dondorp, Joep Geraedts, Luca Gianaroli, K. Ketterson, I. Liebærs, Kersti Lundin, Heidi Mertes, Michael A. Morris, Guido Pennings, Karen Sermon, Claudia Spits, Sirpa Soini, Aafke P.A. van Montfoort, Anna Veiga, Joris Vermeesch, Stéphane Viville, Milan Maçek, on behalf of the European Society of Human Reproduction and Embryology and European Society of Human Genetics   +22 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Clinical genetics in breast cancer. [PDF]

J Surg Oncol
Ntowe KW, Lee MS, Plichta JK.
europepmc   +1 more source

The 2019 US medical genetics workforce: a focus on clinical genetics. [PDF]

Genet Med, 2021
Jenkins BD, Fischer CG, Polito CA, Maiese DR, Keehn AS, Lyon M, Edick MJ, Taylor MRG, Andersson HC, Bodurtha JN, Blitzer MG, Muenke M, Watson MS.   +12 more
europepmc   +1 more source

Clinical significance of tri-nucleotide repeats in Fragile X testing: A clarification of American College of Medical Genetics guidelines [PDF]

, 2008
Kathryn E. Kronquist, Stephanie L. Sherman, Elaine Spector   +2 more
openalex   +1 more source

Genetics and Schizophrenia: A Comprehensive Clinical Analysis

, 2022
Harisoorya A.U., Laveena D’Mello
openalex   +1 more source