Results 61 to 70 of about 9,825,192 (424)
The "new genetics" and clinical practice [PDF]
, 2003 The document attached has been archived with permission from the editor of the Medical Journal of Australia. An external link to the publisher’s copy is included.A "new genetics" has emerged driven by knowledge gained at the DNA level.
Sutherland, G. +2 more
core +1 more source
Efficient inference for genetic association studies with multiple outcomes [PDF]
Biostatistics, 2017, 2016 Combined inference for heterogeneous high-dimensional data is critical in modern biology, where clinical and various kinds of molecular data may be available from a single study. Classical genetic association studies regress a single clinical outcome on many genetic variants one by one, but there is an increasing demand for joint analysis of many ...
arxiv +1 more source
Journal of Genetic Counseling, 2017 International advocacy of patient-centred healthcare delivery has led to emphasis on the (re)design and evaluation of healthcare processes and outcomes from a patient perspective.
A. C. Tirado +6 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Clinical and Genetic Aspects of CADASIL [PDF]
Frontiers in Aging Neuroscience, 2020 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary cerebral small vessel disease caused by mutations in NOTCH3, is characterized by recurrent stroke without vascular risk factors, mood disturbances, and dementia.
Mao Mukai +4 more
openaire +4 more sources
Clinical Genetics in Britain: Origins and development [PDF]
, 2010 Annotated and edited transcript of a Witness Seminar held on 23 September 2008. Introduction by Professor Sir John Bell, Uiversity of Oxford.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2010.©The Trustee of the ...
Harper, PS, Reynolds, LA, Tansey, EM
core
A Partially Functional Linear Modeling Framework for Integrating Genetic, Imaging, and Clinical Data [PDF]
arXiv, 2022 This paper is motivated by the joint analysis of genetic, imaging, and clinical (GIC) data collected in the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. We propose a regression framework based on partially functional linear regression models to map high-dimensional GIC-related pathways for Alzheimer's Disease (AD). We develop a joint model
arxiv
Recontact in clinical practice: a survey of clinical genetics services in the United Kingdom
Genetics in Medicine, 2016 Purpose:To ascertain whether and how recontacting occurs in the United Kingdom.Method:A Web-based survey was administered online between October 2014 and July 2015. A link to the survey was circulated via an e-mail invitation to the clinical leads of the
D. Carrieri +6 more
semanticscholar +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Chronological relationship between antisocial personality disorder and alcohol dependence [PDF]
, 2002 Personality disorders, and particularly antisocial personality disorder (ASPD), frequently co-occur with alcohol dependence. ASPD is considered to be an important cofactor in the pathogenesis and clinical course of alcohol dependence.
Bahlmann, Miriam +2 more
core +1 more source