Results 151 to 160 of about 6,212,196 (310)
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection
FEBS Open Bio, EarlyView.Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow +12 more
wiley +1 more source
Decentralised Clinical Guidelines Modelling with Lightweight Coordination Calculus
, 2007 Background:Clinical protocols and guidelines have been considered as a major means to ensure that cost-effective services are provided at the point of care.
Lewis, Paul +3 more
core +1 more source
FEBS Open Bio, EarlyView.Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia +9 more
wiley +1 more source
Cell surface CD11c as a neutrophil aging marker molecule
FEBS Open Bio, EarlyView.Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki +5 more
wiley +1 more source
Do we know what makes a good clinical guideline?
Zdravniški Vestnik, 2016 Clinical guideline is systematically developed set of statements and assist a doctor, other health care practitioners and patients to make decisions about appropriate health care for specific clinical circumstances.They are produced under the auspices of
Ksenija Gersak, Zlatko Fras, Miran Rems
doaj
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
Implementing evidence-based practice in primary care: perceptions of a multifaceted programme to encourage guideline use [PDF]
, 2002 Objective To explore the acceptability of the various elements of a multifaceted intervention designed to facilitate the process of guideline implementation by primary care teams and to understand constraints to the use of guidelines in this setting.
Kaba, Evridiki +4 more
core
Guidelines for Stroke Critical Rehabilitation
康复学报Stroke is a disease in which cerebral blood vessels are damaged by a variety of causes, producing focal or overall brain tissue damage. With the acceleration of population aging and urbanization, stroke has become the leading cause of death and ...
PAN Yu +18 more
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