Results 141 to 150 of about 6,212,196 (310)

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update.

, 2018
The purpose of this guideline is to provide information for the interpretation of clinical dihydropyrimidine dehydrogenase (DPYD) genotype tests so that the results can be used to guide dosing of fluoropyrimidines (5-fluorouracil and capecitabine ...
Schellens, Jan H M, Swen, Jesse J, McLeod, Howard L, Caudle, Kelly E, Klein, Teri E, Schwab, Matthias, Offer, Steven M, Barbarino, Julia, Amstutz, Ursula, Henricks, Linda M, Diasio, Robert B   +10 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

NICEly does it: economic analysis within evidence-based clinical practice guidelines [PDF]

There is increasing professional and policy interest in the role of clinical guidelines for promoting effective and efficient health care. The NHS Health Technology Assessment Programme identified an urgent need, when such guidelines are produced, to ...
Nick Freemantle, Martin Eccles, Mike Drummond, James Mason   +3 more
core  

Systematic review-based guideline “Parkinson’s disease” of the German Society of Neurology: diagnostic use of transcranial sonography [PDF]

Background and objective Transcranial brain parenchyma sonography (TCS) has been recommended as a tool for the early and differential diagnosis of Parkinson’s disease (PD) in German and European clinical guidelines.
Höglinger, Günter, for the German Parkinson Guideline Group, Storch, Alexander, Loewenbrück, Kai F., Trenkwalder, Claudia, Walter, Uwe, Dodel, Richard   +6 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

ESCMID Guideline for the Management of Acute Sore Throat

, 2012
The European Society for Clinical Microbiology and Infectious Diseases established the Sore Throat Guideline Group to write an updated guideline to diagnose and treat patients with acute sore throat.
Little, P., ESCMID Sore Throat Guideline Group, Verheij, T., T. Verheij, Grigoryan, L., Pelucchi, C., C. Pelucchi, Esposito, S., Huovinen, P., Galeone, C., C. Galeone, Esposito, Susanna Maria Roberta, Espesito, S., P. Little, S. Esposito, Verheij, Th.J.M., L. Grigoryan, P. Huovinen, General Practice & Nursing Science, JC onderzoeksprogramma Infectious Diseases, Infection & Immunity, Epidemiology & Health Economics   +21 more
core   +1 more source

Guidelines for Stroke Critical Care Rehabilitation

康复学报
Stroke is a disease in which cerebral blood vessels are damaged by a variety of causes, producing focal or overall brain tissue damage. With the acceleration of population aging and urbanization, stroke has become the leading cause of death and ...
PAN Yu, XIE Yuxiao, ZHANG Hao, LYU Zeping, XIE Qing, BAI Dingqun, WAN Chunxiao, JIANG Shan, HE Jing, LIU Shaxin, LI Chong, YANG Bing, LIU Weiming, YANG Guofa, ZHOU Hua, LI Xin, XIE Ruimou, NI Xueyi, MA Di   +18 more
doaj  

Editorial: Clinical guidelines in schizophrenia: applications and evaluation

Frontiers in Psychiatry, 2023
Shinsuke Hidese, Signe Düring, Rafael Penadés   +2 more
doaj   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source