Results 121 to 130 of about 423,814 (311)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

DEP CG7 Ambulant mobilty aids and standing positioning equipment

, 2014
This clinical guideline for professional in using ambulant mobility aids and standing positioning equipment.Aged and Disability ...
Clinical Reference Group
core  

Outcomes for depression and anxiety in primary care and details of treatment: a naturalistic longitudinal study

, 2011
Background There is little evidence as to whether or not guideline concordant care in general practice results in better clinical outcomes for people with anxiety and depression.
Peter FM Verhaak, Hilbink-Smolders Mirrian, Verhaak Peter FM, Penninx Brenda WJH, Hilbink-Smolders, Mirrian, Peter Spreeuwenberg, Spreeuwenberg, Peter, Bensing, Jozien M, Brenda WJH Penninx, Verhaak, P.F.M., Hilbink-Smolders, M., {Van Der Meer}, Klaas, Prins, Marijn A, van der Meer, K., Marijn A Prins, Laurant, M.G., Bensing, J.M., van der Meer Klaas, van Marwijk, H.W.J., Verhaak, P.F., van Marwijk Harm WJ, van Marwijk, Harm W. J., Prins, Marijn A., Verhaak, Peter F M, Prins, M.A., Penninx, B.W.J.H., Laurant Miranda GH, Prins Marijn A, Verhaak, Peter F. M., Klaas van der Meer, Marwijk, H.W.J. van, Spreeuwenberg Peter, Harm WJ van Marwijk, Bensing Jozien M, Van Marwijk, Harm, Penninx, Brenda W. J. H., Meer, K. van der, Spreeuwenberg, P., Laurant, Miranda G H, Laurant, Miranda G. H., Miranda GH Laurant, Penninx, Brenda W J H, Laurant, M.G.H., van der Meer, Klaas, Bensing, Jozien M., Jozien M Bensing, Mirrian Hilbink-Smolders   +46 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The use of art work in art psychotherapy with people who are prone to psychotic states: an evidence-based clinical practice guideline

, 2007
This Clinical Guideline addresses the evidence base for the theory and practice of Art Psychotherapy for clients who have severe and complex problems.
Gilroy, Andrea, Ringrose, Kate, Waldman, Judith, Brooker, Julie, McCombe, Brian, Mahony, Jacky, Smart, Louise, Zweigbergk, Britta von, Russell, Denise, Cullum, Michael   +9 more
core  

Challenges in developing national HIV guidelines: experience from the eastern Mediterranean

, 2011
OBJECTIVE: To appraise the process of development and clinical content of national human immunodeficiency virus (HIV) clinical practice guidelines of countries in the eastern Mediterranean and to formulate recommendations for future guideline development
Zolfo, M., Maria Zolfo, Bortolotti, V., Siobhan Crowley, Crowley, S., Lynen, L., Robert Colebunders, De Weggheleire, A., Lutgarde Lynen, Anja De Weggheleire, Veronique Bortolotti, Riedner, G., Colebunders, R., Gabriele Riedner   +13 more
core   +1 more source

Optimizing the Routine Use of Clinical Guidelines by Addition of Supplements (Probiotics and/or Bismuth) to Helicobacter pylori Eradication Protocols in a Clarithromycin Resistant and Tetracycline/Bismuth Naive Area: A Real-World Data Retrospective Analysis of 402 Cases (2016–24) in a Single Gastroenterology Unit

Antibiotics
Background: The official current guideline for Helicobacter pylori (H. pylori) eradication is to use tetracycline–bismuth-based protocols as first line treatment due to the increasing incidence of clarithromycin resistance in the last decade.
András Gelley, Noémi Kéri, Péter Birinyi, Kinga Komka, Vajk Hardy, László Döngölő, Dóra Szeli, Ibolya Czegle   +7 more
doaj   +1 more source

The American Society of Pain and Neuroscience (ASPN) Evidence-Based Clinical Guideline of Interventional Treatments for Low Back Pain [Corrigendum]

Journal of Pain Research, 2022
Sayed D, Grider J, Strand N, et al. J Pain Res. 2022;15:3729-3832. The authors have advised that there is an error in Table 32 on page 3797. Row six Gilligan et al 2021, fourth column level of evidence, the text “I-C” should read “I ...
Sayed D, Grider J, Strand N, Hagedorn JM, Falowski S, Lam CM, Tieppo Francio V, Beall DP, Tomycz ND, Davanzo JR, Aiyer R, Lee DW, Kalia H, Sheen S, Malinowski MN, Verdolin M, Vodapally S, Carayannopoulos A, Jain S, Azeem N, Tolba R, Chang Chien GC, Ghosh P, Mazzola AJ, Amirdelfan K, Chakravarthy K, Petersen E, Schatman ME, Deer T   +28 more
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source