Results 101 to 110 of about 6,212,196 (310)

Transforming evidence-based clinical guidelines into implementable clinical decision support services: the CAREPATH study for multimorbidity management

Frontiers in Medicine
IntroductionThe CAREPATH Project aims to develop a patient-centered integrated care platform tailored to older adults with multimorbidity, including mild cognitive impairment (MCI) or mild dementia.
Mert Gencturk, Gokce B. Laleci Erturkmen, A. Emre Akpinar, A. Emre Akpinar, Omid Pournik, Bilal Ahmad, Theodoros N. Arvanitis, Theodoros N. Arvanitis, Wolfgang Schmidt-Barzynski, Tim Robbins, Ruben Alcantud Corcoles, Ruben Alcantud Corcoles, Pedro Abizanda, Pedro Abizanda, Pedro Abizanda   +14 more
doaj   +1 more source

Improving the Applicability and Feasibility of Clinical Practice Guidelines in Primary Care: Recommendations for Guideline Development and Implementation

Risk Management and Healthcare Policy, 2021
Lu Han,1,2 Linan Zeng,1,2 Yanjun Duan,3 Kexin Chen,4 Jiajie Yu,5 Honghao Li,6 Qiusha Yi,1,2 Youping Li,5 Lingli Zhang1,2 1Department of Pharmacy/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, Sichuan ...
Han L, Zeng L, Duan Y, Chen K, Yu J, Li H, Yi Q, Li Y, Zhang L   +8 more
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Diagnosis and staging of patients with ovarian cancer National Clinical Guideline No. 20: Summary

, 2019
This summary should be read in conjunction with the full version National Clinical Guideline. The full version is available at: https://health.gov.ie/national-patient-safety-office/ncec/national-clinical-guidelines/. The complete list of appendices can
Department of Health
core  

How to develop a National Clinical Guideline: A manual for guideline developers [PDF]

, 2019
This manual establishes a framework for guideline development in Ireland. The first edition was published in 2013. It was developed to support guideline development group members to prepare their guidelines and submit to the NCEC for prioritisation ...
Department of Health (DoH), National Clinical Effectiveness Committee (NCEC)   +1 more
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

National Clinical Guideline: Management of Chronic Obstructive Pulmonary Disease (COPD) [v5.0] [PDF]

, 2020
This National Clinical Guideline applies to the management of adults with COPD. . This National Clinical Guideline is relevant to all healthcare professionals caring for people with COPD.
National Clinical Effectiveness Committee
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Diagnosis, staging and treatment of patients with gestational trophoblastic disease

, 2015
This guideline is intended for all health professionals involved in the diagnosis, staging and treatment of patients with GTD, such as gynaecologists, radiologists, pathologists, surgeons, medical oncologists, GPs and nursing staff.
National Clinical Effectiveness Committee (NCEC)
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source