Results 131 to 140 of about 9,065,236 (261)

Registered nurses' experiences of non-nurses being involved in nursing care to hospitalised patients – A focus group study

Nordic Journal of Nursing Research
The aim of this study was to explore registered nurses’ experiences of non-nurses being involved in nursing care of hospitalised patients at a Danish university hospital.
Helle Enggaard, Britt Laugesen, Kathrine Hoffmann Kusk, Karin Bundgaard, Helle Haslund-Thomsen, Sara Jacobsen, Siri Lygum Voldbjerg, Birgitte Lerbæk   +7 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The ESCMID Framework for Reaching Consensus in Clinical Guidelines

Scope: As the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) continues to expand its guidelines programme, further methodological standardisation is needed. This project aimed to develop a framework for standardising consensus
Molina, Jose, Scudeller, Luigia, Paño-Pardo, José Ramón, Bodilsen, Jacob, Tacconelli, Evelina, Stahl, Jean Paul, Nagavci, Blin, Kostyanev, Tomislav, the ESCMID Guidelines Subcommittee, Joean, Oana, Zervos, Marcus, Tschudin-Sutter, Sarah, Paul, Mical, Langendam, Miranda, Bodilsen, Jacob; id_orcid   +14 more
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials

, 2019
OBJECTIVE: To revise the 1999 Airlie House consensus guidelines for the design and implementation of preclinical therapeutic studies and clinical trials in amyotrophic lateral sclerosis (ALS).
Airlie House ALS Clinical Trials Guidelines Group, Regenerative Medicine and Stem Cells, Brain, ZL Neuromusculaire Ziekten Medisch, Projectafdeling ALS   +4 more
core  

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Editor's Choice -- European Society for Vascular Surgery (ESVS) 2025 Clinical Practice Guidelines on the Management of Vascular Trauma

OBJECTIVE: The European Society for Vascular Surgery (ESVS) has developed clinical practice guidelines for the care of patients with vascular trauma with the aim of assisting physicians in selecting the optimal management strategy.METHODS: The guidelines
Dubose, Joseph J.,, Vega de Ceniga, Melina, Boyle, Jonathan R.,, Ruffino, M.A., Blair, Paul,, de Ceniga, Melina Vega,, Van Herzeele, Isabelle,, Kakkos, Stavros K, Civil, Ian D.S., Jongkind, V., Piffaretti, G., ESVS Guidelines Committee, [missing], Wahlgren, Carl Magnus,, DuBose, Joseph J, Twine, Christopher P.,, Van Herzeele, Isabelle, Boyle, Jonathan R., DuBose, J.J., Heim, C., Wahlgren, C.M., Mitchell, Erica L, Piffaretti, Gabriele,, Wanhainen, Anders,, Wipper, S., Mees, BME, Antoniou, George A., Trimarchi, Santi,, Wipper, Sabine, Dias, N.V., Engelhardt, Michael,, Coscas, Raphael,, Aylwin, C., Mitchell, E.L., Jorgensen, Joakim, Boyle, Jonathan R, Gaarder, C., Dubose, Joseph J., Civil, Ian D. S.,, Wipper, Sabine,, Kakkos, S.K., Dias, Nuno V., Civil, Ian D. S., Ruffino, Maria Antonella, Wanhainen, A., Vikatmaa, Pirkka, Mees, Barend M.E., Mees, Barend M. E.,, Aylwin, Christopher, Ruffino, Maria Antonella,, Ricco, Jean-Baptiste,, de Ceniga, Melina Vega, Kakkos, Stavros K.,, Twine, Christopher P, Mees, Barend M. E., Dias, Nuno, V, Vikatmaa, P., Antoniou, G.A., Brohi, Karim, Coscas, Raphaël, Civil, Ian D S, Davenport, Ross A, Heim, Catherine, Blair, P., Engelhardt, M., Coscas, R., Heim, Catherine,, Davidovic, Lazar B, Wanhainen, Anders, Trimarchi, Santi, Dias, Nuno, V,, Ricco, J.B., ?, ?, Mcgreevy, David T., Gaarder, Christine,, Davenport, Ross A.,, Jongkind, Vincent,, Antoniou, George A.,, Davenport, R.A., Twine, C.P., Piffaretti, Gabriele, Wahlgren, Carl Magnus, Trimarchi, S., McGreevy, David T, Blair, Paul, Antoniou, George A, Vega de Ceniga, M., Davenport, Ross A., Jorgensen, Joakim,, McGreevy, D.T., Aylwin, Christopher,, Van Herzeele, I., JørgensenIn, Joakim, Mees, Barend M E, Davidovic, Lazar B.,, Twine, Christopher P., Jongkind, Vincent, Dias, Nuno V, Ricco, Jean-Baptiste, Mitchell, Erica L.,, Brohi, K., Davidovic, Lazar B., Vikatmaa, Pirkka,, Boyle, J.R., Engelhardt, Michael, Mitchell, Erica L., Jørgensen, J., Mcgreevy, David T.,, Gaarder, Christine, Brohi, Karim,, Kakkos, Stavros K., ESVS Guidelines Committee, George A., Davidovic, L.B., Civil, IDS, Dias, Nuno, Jørgensen, Joakim   +114 more
core   +1 more source