Results 81 to 90 of about 9,065,236 (261)

Clinical guidelines: Using clinical guidelines

The implementation of clinical guidelines within a clinical governance setting requires time, enthusiasm, and resources. Local groups should adopt pre-existing valid guidelines. Implementation activity should draw on the available evidence.
Griffiths C, Feder G, Grol R, Eccles M, Grimshaw J   +4 more
core   +4 more sources

Singapore tuberculosis (TB) clinical management guidelines 2024: A modified Delphi adaptation of international guidelines for drug-susceptible TB infection and pulmonary disease

Annals, Academy of Medicine, Singapore
Introduction: Tuberculosis (TB) remains endemic in Singapore. Singapore’s clinical practice guidelines for the management of tuberculosis were first published in 2016.
Michelle Lay Teng Ang, Si Min Chan, Lionel Tim-Ee Cheng, Hau Yiang Cheong, Ka Lip Chew, Piotr Maciej Chlebicki, Li Yang Hsu, Gregory Jon Leng Kaw, Adrian Chin Leong Kee, Mark Chung Wai Ng, Rick Twee Hee Ong, Catherine Wei Min Ong, Jessica Lishan Quah, Balasubramaniam D/O Selvamani, Li Hwei Sng, Jamie Bee Xian Tan, Cher Heng Tan, Jun Yang Tay, Lynette Li San Teo, Koh Cheng Thoon, Gabriel Zherong Yan, Jacinta I-Pei Chen, Mohammed Helmi bin Hud, Benjamin Bing Jie Khoo, Dawn Yi Xin Lee, Bob Xian Yi Ng, Jia Ying Park, Belinda Ying Ting Tan, Qian Yang   +28 more
doaj   +1 more source

Clinical Guidelines for Opioid Substitution Treatment [PDF]

The Guidelines have been developed in order to outline evidence-based care to standardise and improve the quality and safety of care to the patient.Published Dec 2016.
Clinical Design & Innovation
core  

Authorship in reports of clinical practice guidelines: A systematic cross-sectional analysis [PDF]

, 2018
Background: A transparent and explicit reporting on authors’ contributions to the development of clinical practice guidelines and on panelists’ characteristics is essential for their credibility and trustworthiness.
Semaan, Aline T., Ahmed Ali, Maya Diab, Daou, Karim N., Khamis, Assem M., Akl, Elie A., Ali, Ahmed K., Diab, Maya, Assem M. Khamis, Aline T. Semaan, Karim N. Daou, Nomier, Mohamed A., Mohamed Nomier, Elie A. Akl   +13 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Assessing the impact of a nutrition educational video on health-related quality of life in older home-living adults after discharge from a surgical hospital department: a randomised controlled pilot trial

BMC Nutrition
Background Health-related quality of life (HRQoL) is a broad multidimensional concept linked to nutritional status in older adults. This study aimed to estimate the impact of an educational video on nutrition on HRQoL among older adults during the first ...
Monica Christin Hansen, Kari Ingstad, Lisbeth Uhrenfeldt, Preben U. Pedersen   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Bilan des études sur les guides de pratique en santé : qu’en retirer pour la santé et la sécurité au travail

Perspectives Interdisciplinaires sur le Travail et la Santé, 2012
The development and assessment of clinical practice guidelines has been the subject of numerous studies and analyses. Such guidelines are seen as an optimal way to ensure knowledge transfer and thereby disseminate and rationalize best practices.
Monique Lortie, Cheikh Faye, Elena Laroche, Lise Desmarais, Denys Denis, Iuliana Nastasia, Sylvie Gravel, Laurent Giraud   +7 more
doaj   +1 more source

The Royal College of Ophthalmologists Guidelines on AMD: executive summary

, 2013
Age-related macular degeneration (AMD) is a common condition in older adults. Since publication of the last guidelines in 2009, new data have emerged on the management of AMD and novel solutions have been tested to meet the ongoing challenge of AMD ...
AMD Guidelines Group,, Williams, M., Chakravarthy, U.   +2 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source