Results 121 to 130 of about 5,841,868 (306)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The Role of Trauma and Stressful Life Events among Individuals at Clinical High Risk for Psychosis: A Review

Frontiers in Psychiatry, 2017
The experience of childhood trauma (CT) and stressful life events (SLEs) is associated with subsequent development of a variety of mental health conditions, including psychotic illness. Recent research identifying adolescents and young adults at clinical
Danessa Mayo, Sarah Corey, Leah H. Kelly, Seghel Yohannes, Alyssa L. Youngquist, Barbara K. Stuart, Tara A. Niendam, Rachel L. Loewy   +7 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A Recovery-Oriented Approach: Application of Metacognitive Reflection and Insight Therapy (MERIT) for Youth with Clinical High Risk (CHR) for Psychosis

Behavioral Sciences
Clinical High Risk for psychosis (CHR) refers to a phase of heightened risk for developing overt psychosis. CHR often emerges during adolescence or early adulthood.
Bethany L. Leonhardt, Andrew C. Visco, Jay A. Hamm, Jenifer L. Vohs   +3 more
doaj   +1 more source

A survey of relative frequency of etiologies, time of onset, efficacy of drug therapy and risk factors for clinical neonatal seizures [PDF]

Introduction: Seizure is a common condition in neonatal period and may become first feature of neurologic dysfunction. In most cases, diagnosis of neonatal seizure and its different etiologies are based on history, clinical manifestations and ...
براک, منوچهر, معماری, احد, میرزا رحیمی, مهرداد, پوستی, علیرضا   +3 more
core  

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Individualized Prediction of Transition to Psychosis in 1,676 Individuals at Clinical High Risk: Development and Validation of a Multivariable Prediction Model Based on Individual Patient Data Meta-Analysis

Frontiers in Psychiatry, 2019
Background: The Clinical High Risk state for Psychosis (CHR-P) has become the cornerstone of modern preventive psychiatry. The next stage of clinical advancements rests on the ability to formulate a more accurate prognostic estimate at the individual ...
Aaltsje Malda, Aaltsje Malda, Nynke Boonstra, Nynke Boonstra, Hans Barf, Steven de Jong, Andre Aleman, Andre Aleman, Jean Addington, Marita Pruessner, Marita Pruessner, Dorien Nieman, Lieuwe de Haan, Anthony Morrison, Anthony Morrison, Anita Riecher-Rössler, Erich Studerus, Stephan Ruhrmann, Frauke Schultze-Lutter, Suk Kyoon An, Shinsuke Koike, Shinsuke Koike, Shinsuke Koike, Shinsuke Koike, Kiyoto Kasai, Kiyoto Kasai, Kiyoto Kasai, Kiyoto Kasai, Barnaby Nelson, Barnaby Nelson, Patrick McGorry, Patrick McGorry, Stephen Wood, Stephen Wood, Stephen Wood, Ashleigh Lin, Alison Y. Yung, Alison Y. Yung, Alison Y. Yung, Alison Y. Yung, Magdalena Kotlicka-Antczak, Marco Armando, Marco Armando, Stefano Vicari, Masahiro Katsura, Kazunori Matsumoto, Kazunori Matsumoto, Kazunori Matsumoto, Sarah Durston, Tim Ziermans, Tim Ziermans, Lex Wunderink, Lex Wunderink, Helga Ising, Mark van der Gaag, Mark van der Gaag, Paolo Fusar-Poli, Paolo Fusar-Poli, Paolo Fusar-Poli, Paolo Fusar-Poli, Gerdina Hendrika Maria Pijnenborg, Gerdina Hendrika Maria Pijnenborg   +61 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Biomarkers Beyond the Natriuretic Peptides for Chronic Heart Failure: Galectin-3 and Soluble ST2. [PDF]

, 2012
B-type natriuretic peptide (BNP) and NT-proBNP are widely used plasma biomarkers for the diagnosis of acute decompensated heart failure and prognosis for future cardiac disease.
Wu, Alan HB
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source