Results 71 to 80 of about 6,307,860 (296)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Factors associated with serious adverse event following immunization: a real-world analysis of the vaccine adverse event reporting system 2025

Frontiers in Public Health
Background and aimsWhile vaccination is a vital and cost-effective public health tool, a small fraction of recipients experience serious adverse events (SAEs) that impose a profound clinical and systemic burden.
Xuejiao Pan, Yaping Chen, Fuxing Chen, Hanqing He, Xiaohua Qi, Hui Liang   +5 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

A context-aware interpretive framework for lymphocyte immunophenotyping by flow cytometry

Frontiers in Immunology
BackgroundFlow cytometry–based immunophenotyping is a powerful tool in clinical and translational immunology; however, the interpretation of lymphocyte immunophenotype results remains incomplete, despite extensive methodological standardization.
Carlos Agustin Villegas-Valverde, Yendry Ventura-Carmenate   +1 more
doaj   +1 more source

Important questions in drug allergy and hypersensitivity: consensus papers from the 2018 AAAAI/WAO international drug allergy symposium

World Allergy Organization Journal, 2018
This article is one of a series of international consensus documents developed from the International Drug Allergy Symposium held at the Joint Congress of the American Academy of Allergy, Asthma & Immunology/World Allergy Organization on March 1, 2018 ...
Pascal Demoly, Mariana Castells
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

CURRENT CHALLENGES, RECENT ACHIEVEMENTS, AND FUTURE DIRECTIONS FOR THE DEVELOPMENT OF IMMUNOLOGY, ALLERGOLOGY, AND RHEUMATOLOGY

Proceedings of the Shevchenko Scientific Society: Medical Sciences
Clinical immunology, allergology, and rheumatology play a vital role in modern medicine, combining fundamental scientific research with practical healthcare.
Svitlana Zubchenko, Marta Lomikovska, Serhii Yuriev   +2 more
doaj   +1 more source

A real-world intention-to-treat analysis of a decade’s experience of treatment of hepatitis C with interferon-based therapies [version 1; referees: 2 approved]

F1000Research, 2016
Objectives: To assess the uptake of pegylated interferon (PegIFN) plus ribavirin (RBV)-based regimens in patients with hepatitis C virus (HCV) in a large, single-centre, real-world setting over 10 years.
Nowlan Selvapatt, Ashley Brown
doaj   +1 more source

A randomized, phase II study of sequential belimumab and rituximab in primary Sjögren’s syndrome

JCI Insight, 2022
BACKGROUND Primary Sjögren’s syndrome (pSS) is characterized by B cell hyperactivity and elevated B-lymphocyte stimulator (BLyS). Anti-BLyS treatment (e.g., belimumab) increases peripheral memory B cells; decreases naive, activated, and plasma B cell ...
Xavier Mariette, Francesca Barone, Chiara Baldini, Hendrika Bootsma, Kenneth L. Clark, Salvatore De Vita, David H. Gardner, Robert B. Henderson, Michael Herdman, Karoline Lerang, Prafull Mistry, Raj Punwaney, Raphaele Seror, John Stone, Paul L.A. van Daele, André van Maurik, Nicolas Wisniacki, David A. Roth, Paul Peter Tak   +18 more
doaj   +1 more source

Performance of Large Language Models in Medical Exams: A Review Focusing on Allergy, Immunology, and Related Fields

The emergence of large language models (LLMs) presents significant opportunities in healthcare and medical education. This study evaluates the performance of LLMs in medical examinations, with a specific focus on allergy, immunology, and related ...
Yildirim, Onur Can, Dumanoglu, Betul, Can Bostan, Ozge, Cerci, Pamir   +3 more
core   +1 more source