Results 191 to 200 of about 428,100 (253)

Biodegradable Zn‐Based Implants: Progress, Challenges, and Pathways toward Clinical Translation

Advanced Science, EarlyView.
Exploring biodegradable Zn‐based implants offers a promising pathway to next‐generation biomedical devices with balanced degradation and biocompatibility. A comprehensive overview of biodegradable Zn‐based implants, covering their biological significance, material design principles, and advanced engineering strategies is provided.
Panfeng Zhao, Zhengquan Wang, Hui Yang, Xiyuan Zhang, Hanyuan Liu, Xiaotong Lu, Xiaocheng Li, Yanyan Liu, Xi Zhao, Wenhao Zhou, Yufeng Zheng   +10 more
wiley   +1 more source

Microcosting the optimization of PrEP implementation among sexual and gender minority individuals with a substance use disorder. [PDF]

Addict Sci Clin Pract
Ryan D, Reback CJ, Mata RP, Li M, Jalali A, Jeng PJ, Benkeser D, Murphy SM.   +7 more
europepmc   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Enhancing clinical laboratory quality in Rwanda: addressing healthcare expectations and future fitness - insights from observations and perspectives of physicians and laboratory professionals. [PDF]

BMC Health Serv Res
Nzabahimana I, Namatovu F, Uwineza A, Rusanganwa V.   +3 more
europepmc   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Fluorescein Interferes With Hemoglobin Measurement During Intra-operative Point-of-Care Blood Gas Analysis: A Clinical Observation. [PDF]

Cureus
Kojima Y, Moriwaki T, Kitamura H, Nakano K, Hirabayashi K.   +4 more
europepmc   +1 more source

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

Beyond hematopoietic stem cell transplantation: positioning Africa for scalable uptake of innovative sickle cell therapies. [PDF]

BMJ Glob Health
Agu CB, Abdulkareem R, Ajah CM, Ogunniyi TJ, Ndubisi AC.   +4 more
europepmc   +1 more source

Detection of repeat expansion variants using next generation sequencing: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG). [PDF]

Genet Med
Guha S, Rajan-Babu IS, Kesari A, Garg S, Rose NC, Seifert BA, Reddi HV, ACMG Laboratory Quality Assurance Committee. Electronic address: documents@acmg.net.   +7 more
europepmc   +1 more source

Screen-and-treat: a sustainable solution for cervical cancer elimination in low and middle income countries. [PDF]

BMJ Oncol
Cardoso L, Saidu R, Kuhn L.
europepmc   +1 more source