Results 101 to 110 of about 878,073 (326)

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source

Unsupervised Learning for Computational Phenotyping [PDF]

arXiv, 2016
With large volumes of health care data comes the research area of computational phenotyping, making use of techniques such as machine learning to describe illnesses and other clinical concepts from the data itself. The "traditional" approach of using supervised learning relies on a domain expert, and has two main limitations: requiring skilled humans ...
arxiv  

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source

Diabetes Mellitus among new tuberculosis patients in Bamako, Mali

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2019
Introduction: Diabetes Mellitus (DM) increases worldwide, mostly in low- and middle-income countries. In Mali, the prevalence in the adult population is estimated at 1.8%, but tuberculosis (TB) patients are not systematically screened.
B. Diarra, M. Tolofoudie, Y.S. Sarro, A.C.G. Togo, S. Bane, I. Nientao, A.B. Cisse, M. Kone, A. Somboro, B. Degoga, F. Diallo, G. Coulibaly, O. Kodio, M. Sanogo, B. Kone, S. Diabate, B. Baya, A. Kone, D. Dabitao, M. Maiga, M. Belson, S. Dao, I.I. Maiga, R.L. Murphy, S. Siddiqui, Y. Toloba, B. Konate, S. Doumbia, B.C. de Jong, S. Diallo   +29 more
doaj  

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Epidemiological and clinical characteristics of cutaneous leishmaniasis and their relationship with the laboratory data, south of Brazil

Brazilian Journal of Infectious Diseases
OBJECTIVE: To evaluate clinical, epidemiological and laboratorial aspects for the understanding of the disease characteristics and its relationship with diagnostic tests. METHODS: A retrospective, descriptive and analytical study involving 2,660 American
Maura Cristiani de Moura Curti, Thaís Gomes Verzignassi Silveira, Sandra Mara Alessi Aristides Arraes, Dennis Armando Bertolini, Paulo Donizeti Zanzarini, Eneide Aparecida Sabaini Venazzi, Andrea Cláudia Silva Fernandes, Jorge Juarez Vieira Teixeira, Maria Valdrinez Campana Lonardoni   +8 more
doaj   +1 more source

Prevalence of trichomonas vaginalis in women attended at a private laboratory

DST, 2021
Introduction: Sexually Transmitted Infections (STIs) are caused by viruses, fungi, bacteria, or other microorganisms, thus being a serious public health issue. Trichomonas vaginalis is the disease causative agent of trichomoniasis, a worldwide protozoan.
Fernanda Nívian Brito da Silva, Lorena Alcântara de Farias, Nayara Santos de Oliveira, Renata Mirian Nunes Eleutério, Cristina Tonin Beneli Fontanezi   +4 more
doaj  

A Technique for von Willebrand Multimer Analysis Applicable to the Clinical Laboratory

Clinical and Applied Thrombosis/Hemostasis, 1995
In type I von Willebrand disease, the whole series of von Willebrand factor multimers is present in plasma. However, in type II von Willebrand disease qual itative defects of the von Willebrand factor proteins exist. Using a novel semidry horizontal gel electrophoresis ap paratus combined with a discontinuous buffer system, high-resolution analysis of
William L. Bayer, Michael R. Coon
openaire   +2 more sources

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

Molecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen, Pieter‐Jan Volders, Ellen Geerdens, Severine Berden, Joni Van der Meulen, Aaron De Cock, Stefanie Vermeire, Jacques Van Huysse, Marie de Barsy, Gabriela Beniuga, Wendy W. J. de Leng, Anne M. L. Jansen, Imke Demers, Zeliha Ozgur, Hendrikus Jan Dubbink, Ernst‐Jan M. Speel, Wilfred F. J. van IJcken, Brigitte Maes   +17 more
wiley   +1 more source