Results 121 to 130 of about 2,224,952 (265)

A Large Multicenter Cohort of Ataxia-Telangiectasia: Clinical, Immunologic, Genetic, and Survival Outcomes. [PDF]

Eur J Neurol
Fekrvand S, Firouzabadi A, Vakilipour P, Safari D, Delavari S, Mehrabadi AZ, Chavoshzadeh Z, Esmaeilzadeh H, Sharafian S, DorriMoghaddam F, Sadeghi-Shabestari M, Monfared FT, Afkham EK, Aleyasin S, Abolnezhadian F, Salyanchi R, Ahanchian H, Kalantari A, Behniafard N, Momen T, Sherkat R, Tavakol M, Barzamini S, Shafiei A, Cheraghi T, Vosughimotlagh A, Sepahi N, Olbrich P, Meyts I, Gennery AR, Abolhassani H, Rezaei N, Yazdani R.   +32 more
europepmc   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Correction: Comparative effectiveness of daytime versus nighttime paravertebral block analgesia on intraoperative hemodynamics in older lung cancer patients: a target trial emulation study. [PDF]

Front Med (Lausanne)
Wang Q, Zhuo L, Zhang Y, Zhang B, Yang K, Wei S, Yang J, Ma X, Han X, Zheng H, Xu Y.   +10 more
europepmc   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

FAP-Associated Cribriform Morular Thyroid Carcinoma: A Warning Sign for Sigmoid Colon Cancer. [PDF]

United European Gastroenterol J
Liu X, Lin X, Ju M, Liu Q.
europepmc   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Development and psychometric properties evaluation of individualized patient education tool: An exploratory sequential mixed-methods study protocol. [PDF]

PLoS One
Gardashkhani S, Ghafourifard M, Ghahramanian A, Ebadi A, Gilani N.   +4 more
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

COVID-19 Curriculum Disruptions and Future Preparedness in Iranian Medical Education: A National Mixed-Methods Study. [PDF]

Adv Med Educ Pract
Rashidi F, Abed M, Meysamie A, Khabaz Mafinejad M, Takian A.   +4 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source