Results 141 to 150 of about 3,580,948 (312)
Implementation and evolution of the horizontal integration at shiraz medical school
Journal of Advances in Medical Education and Professionalism, 2013 Introduction: General medical education starts with basic sciences which usually continue about 2.5 to 3 years. In this period, the students study basic medical sciences and then start the clinical stage in which they deal with diagnoses, care, and ...
MITRA AMINI +6 more
doaj
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Internal Evaluation of Clinical Departments of Mazandaran University of Medical Sciences
Journal of Mazandaran University of Medical Sciences, 2018 Background and purpose: Internal evaluation is the systematic process of collecting and analyzing information to determine the benefits and disadvantages of a program and the extent to which its objectives are achieved.
Forouzan Sadeghimahalli +4 more
doaj
EFFECTS OF ACOUSTIC STIMULATION ON BIOPHYSICAL PROFILE TESTING TIME [PDF]
Biophysical profile (BPP) test is the most commonly used antenatal test of fetal well-being. Purpose of this study is determining the influence of acoustic stimulation (AS) on BPP testing time.
جاوید مجد, مریم +3 more
core
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Journal of Islamic International Medical College, 2014 Background: Transition from traditional to integrated curriculum has been very slow in Pakistan. However in the last few years there has been tremendous increase in the number of medical schools.
Masood Anwar, Rehan Ahmed Khan
doaj
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source