Results 161 to 170 of about 2,224,952 (265)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan +13 morewiley +1 more sourceLoss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann +11 morewiley +1 more sourcePAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann +10 morewiley +1 more sourceSpatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours +11 morewiley +1 more sourceGlobal Burden of Anorexia Nervosa and Bulimia Nervosa, 1990 to 2023, With Forecasts to 2050: A Global Burden of Disease Study 2023 Analysis.
JAMA PsychiatryBai R, Dong W, Wang X, Zhang A, Santomauro DF, GBD Eating Disorders Collaborators, Aalruz H, Abiodun O, Aboagye RG, Aboshanab KM, Abreu LG, Abu Lila AS, Abukhadijah HJ, Abu-Mahfouz MS, Adamu NL, Adebiyi BO, Adekola SA, Adesina MA, Adewuyi HO, Adhanu AK, Adonteng-Kissi O, Agordoh PD, Agordoh SW, Agostinis Sobrinho C, Ahmad AMR, Ahmad K, Ahmed A, Ahmed MF, Ahmed S, Ajele KW, Akeju OO, Akinmade OV, Akosile W, Akrami AE, Al Athamneh A, Al Awaidy S, Al Maghaireh DF, Al Omari O, Al Zoubi MAM, Alam MK, Alammar MA, Al-Anzi SMF, Albashtawy M, Aldhahir AM, Alemayehu BA, Alhalabi B, Alhalaiqa FN, Alhawajreh MJ, Alhumaidi A, Ali AN, Ali MU, Alinejad Rokny H, Al-Jabi SW, Alkhatib A, Alkubati SA, Al-Marwani S, Almazan JU, Al-Raddadi RM, Alsaif B, Alsharari AF, Alshawish E, Altaany Z, Altwaijri Y, Aman Mohammadi M, Amin TT, Amugsi DA, Anil A, Anil Kumar AHS, Anjana P, Anyasodor AE, Arabi H, Aravkin AY, Areda D, Arias de la Torre J, Armocida B, Arnone D, Arruda GA, Arystan N, Ásgeirsdóttir BB, Ashraf SA, Asiamah-Asare BKY, Atoyebi SB, Atra YA, Ayala CO, Ayuso-Mateos JL, Azzam EMS, B S, Bai-Sesay AU, Balcha WF, Balhara YPS, Balmori-de-la-Miyar J, Balogun OJ, Bani Hani S, Bano F, Barker-Collo SL, Barrow A, Bashir MI, Bashir S, Bashir S, Bashiri A, Bastan MM, Batra K, Beeraka NM, Belancic A, Tune SNBK, Bhadiyadra MS, Bhaskar S, Bhattacharya S, Bisignano C, Bizzozero-Peroni B, Bodur M, Botero-Carvajal A, Breazu A, Busari AO, C S, C J S, Campos-Nonato I, Carvalho S, Castelpietra G, Cembranel F, Chadwick J, Chandika RM, Chandradasa M, Chang Y, Chen H, Choi DW, Choi YJ, Chung S, Cicero AFG, Cioffi I, Clark CCT, Cortese S, Cosentini I, Cosma C, Cruz-Martins N, Cuenca-Martínez F, Dadras O, Dagli N, Dahiya N, Dai X, Dang NB, Darunde RR, Darwesh AM, de la Torre-Luque A, Deekonda S, Derseh HA, Devnath N, Din S, Dönicke J, Dumbili EW, Durmus H, Eboreime E, Ebrahimian Sadabad F, Eddula VR, Elbarazi I, Elhoumed M, ElNahas G, Elnour AA, Elrggal ME, Metwally El-Sayed M, Eltahawy AS, Emesobum MA, Esomchi CN, Fagbamigbe AF, Fakih N, Faris ME, Faro A, Ashfaq F, Fekih-Romdhane F, Filippini T, Finnemore A, Finnemore Capon Diaz SC, Fischer F, Fogacci F, Forner Álvarez C, Fusar-Poli P, Galali Y, Ganiyu KO, Garlasco J, Gebre TS, Gerami Matin A, Getacher L, Ghafoury R, Ghamkhar A, Gharaibeh L, Ghoba S, Gholami E, Gholami Z, Gialluisi A, Giannouli V, Gilani SA, Gökulu G, Golechha M, Golmohammadi M, Gu C, Gulati S, Gutiérrez B, Habteyesus A, Hallit S, Hamarasool FO, Haq MA, Haro JM, Has EMM, Hasan T, Haslam DM, Hasnain MS, Hay SI, Hendy A, Hoek HW, Hong Y, Hoogar P, Hossain MS, Hossain SB, Hosseinzadeh M, Htay MNN, Husain W, Ibitoye SE, Ibrahim FM, Ibrahim R, Abbasi AI, Iqbal D, Iqbal M, Islam MM, Islam MS, Islam MS, Ispriantari A, Iyiola OA, Jabbarinejad R, Jacob J, Jahrami H, Jaka S, Jamal A, Jayapal SK, Jayasinghe YA, Joy GV, Jozwiak JJ, Juweid ME, K HS, Kalra S, Kang K, Kantipudi SJ, Karakasis P, Karnam RP, Kawafha MM, Khacharem A, Khader YS, Khalid S, Khalifeh AH, Khalique N, Khan AA, Khan IW, Khan MI, Khan R, Khan Z, Khasbage SU, Khezeli M, Khoshvaght P, Khotimah FH, Khubchandani J, Kieling C, Kim J, Kondlahalli SKM, Koomson I, Kotsis K, Koul A, Kuan G, Kumah E, Kumar C, Kumar M, Kumar P, Kumar R, Kumar S, Kurpas D, Kusuma D, Lajunen T, Laksono AD, Lasrado S, Latif A, Le LK, Lee HL, Lee SW, Leon-Rojas JE, Li M, Li Z, Lian Y, Liaqat A, Liu Y, Llanaj E, Lopatkina M, López-Gil JF, Luo P, Lushchak O, Lytvyak E, Ma ZF, Mahmood NH, Mahmoud IF, Malkamu B, Mary JJF, Mashudi S, Mathur N, Mattiello R, Mattoo KA, Mazzola G, Mbachu CNP, McGrath JJ, Medina JRC, Mehboob K, Mehboob R, Mehta V, Meto TM, Melariri H, Memon AR, Merlino G, Mestrovic T, Miller PA, Miller TR, Minervini G, Ming LC, Mitra T, Mohamed FI, Mohamed FAEE, Mohammed M, Mohammed Z, Moin A, Mokdad AH, Molinaro S, Monasta L, Morgan AK, Mosaddeghi-Heris R, Mostafa MS, Mughal F, Murray CJL, Muthusamy S, Myung W, Nalabothu P, Naqvi R, Nargus S, Naureen Z, Nguyen CT, Nguyen T, Nigatu YT, Niranjan V, Nkemjika S, Nnyanzi LA, Nouri M, Nzoputam CI, Nzoputam OJ, Okereke P, Olabisi OI, Olagunju AT, Olorunlana A, Ordak M, Ostojic SM, Otekunrin OA, Othman MS, Ozsahin I, Paija DM, Palma-Alvarez RF, Paramashanti BA, Pardhan S, Parikh RR, Park C, Parmar A, Patel BU, Patel M, Patil A, Patil S, Pennisi F, Pereira MO, Perna S, Pham HQ, Porntavetus T, Porru F, Porwal A, Pourghazi F, Puvvula J, Qi X, Qur'aniati N, Radojcic MR, Raggi A, Raghav YS, Rahman M, Rahmawaty S, Rajha H, Rajpoot PL, Rakhymbayev NA, Ramadan MM, Ramadhan K, Rao R, Ravi D, Rawaf S, Rehman A, Rehman W, Rizvi MR, Rolfzen ML, Romadlon DS, Ronfani L, Saddik BA, Sadeghi E, Sadek B, Saeed RF, Sagar R, Saghazadeh A, Sagoe D, Saheb Sharif-Askari N, Sahin Bodur G, Sahni V, Sahu BK, Sakshaug JW, Salaroli LB, Saleh MA, Salum GA, Sankararaman S, Saravanan A, Saylan M, Sethi Y, Shaalan Y, Shaban-Nejad A, Shaharudin S, Shahid SMA, Shahini E, Shahwan MJ, Shaikh MA, Shamim MA, Shamsutdinova A, Shan D, Sharif S, Sharifan A, Sharma G, Sharma K, Sharma S, Sheikh NA, Shetty PK, Shirali PA, Shirazi S, Shokouhifar M, Shomuyiwa DO, Siddique MKB, Siddiqui AJ, Singh A, Singh H, Singh JA, Singh J, Singh PS, Singh S, Singh V, Sridharan K, Stanculescu E, Stokes MA, Stubbs B, Sullman MJM, Sultana M, Tabarés-Seisdedos R, Tabche C, Taha ZM, Taheri N, Tampa M, Tan J, Tan KA, Tao H, Tayarani-Najaran MH, Tekola A, Temsah R, Teramoto M, Thapar R, Trabelsi K, Tran Minh Duc N, Trico D, Tromans SJ, Tsermpini E, Tufail T, Tuglo LS, Sambo AU, Vadakkethil Radhakrishnan R, Vally Z, Van Der Walt G, Vanneste S, Verma AK, Vigezzi GP, Vikram V, Almeida von Humboldt S, Wang S, Wang X, Wang Y, Wickramasinghe ND, Williams F, Wirtu GK, Wonde TE, Yamada N, Yang H, Yano Y, Yergaliyev KA, Yesodharan R, Yismaw YE, Yon DK, Yonemoto N, Zafar MS, Zamagni G, Zarea K, Zargar S, Zastrozhin M, Zawiah M, Zeru EM, Zhang Z, Zyoud SH. +504 moreeuropepmc +1 more source
