Results 151 to 160 of about 3,580,948 (312)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Journal of Clinical and Medical Sciences [PDF]

, 2020
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

9th International Congress of Medical Oncology & Hematology of Iran; 26-28 Nov., 2009 Olympic Hotel Tehran-Iran

International Journal of Hematology-Oncology and Stem Cell Research, 2009
Contents  ◘ Neoadjuvant Chemotherapy in Bladder Cancer Adib Sereshki M.M. Kashan University of Medical Sciences, Iran 1 ◘ New Advances of Proteomics in Early Detection of Pancreatic Cancer Adib sereshki M.M.
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doaj  

Medical lasers—Science and clinical practice [PDF]

Lasers in Medical Science, 1987
openaire   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Different SARS-CoV-2 Subvariants and Coagulation Markers Trend: A Retrospective Multicentric Study From Iranian Network for Research in Viral Diseases (INRVD). [PDF]

Health Sci Rep
Razavi A, Koltapeh MP, Nazari T, Morvaridi A, Banivaheb B, Saeb S, Moulaeian M, Zakaryaei A, Sabzalian A, Raei M, Razavi B, Motlaghzadeh S, Hosseini SS, Karami H, Ghafari P, Aboofazeli A, Nastarvand S, Sarabi NKN, Avakian A, Ebadinejad S, Keyhani T, Danafar P, Rahimlou R, Heidarian S, Mondeali M, Nafe-Monfared F, Jafarpour M, Samiee M, Birang F, Mirzazadeh A, Abadi SAF, Barkhordari K, Siavoshi S, Biklari M, Khodabakhsh M, Javadi A, Mirzaee S, Didgar F, Etebari M, Soltanmohamad S, Shahbaz B, Kord E, Shahri SMH, Ebrahimzade M, Moghaddam AA, Sanavi FS, Moattari A, Edalat F, Sheijani MF, Moghadami M, Yaghubi T, Mojtahedi A, Heidarzadeh A, Naghipour M, Luyeh MS, Nazemi P, Alipasandi K, Albaji M, Afzali M, Shokouhi N, Ezani A, Najari HR, Hosseini M, Ghobadi A, Momeni A, Fattahi SZ, Mohsenzadeh M, Jafari M, Azizi A, Pouryousef S, Tabarraei A, Moradi A, Azimi S, Yahyapour Y, Bayani M, Poortahmasebi V, Varshochi M, Ziaee M, Ghafari S, Javanmard D, Soleimani A, Mozhgani SH, Mokhames Z, Akhoundimeybodi Z, Astani A, Abdollahi A, Hadadi A, Salehi MR, Hajiabdolbaghi M, Raeeskarami SR, Kafan S, Montazeri M, Pazoki M, Riahi T, Talebi-Taher M, Ataei-Pirkooh A, Bokharaei-Salim F, Faiz SHR, Kalantari S, Yasin Z, Jazayeri SM.   +100 more
europepmc   +1 more source