Results 111 to 120 of about 16,573,156 (294)

R. Willan founder of the world scientific dermatology [PDF]

open access: yesСаратовский научно-медицинский журнал, 2017
 The article presents the biography of R. Willan ar|d his scientific and practical contribution to the development of European clinical medicine in the second half of the 18 century and in the establishment of world scientific dermatology.
Betechtin M.S., Zavyalov A.I.
doaj  

The rationale behind systematic reviews in clinical medicine: a conceptual framework

open access: yesJournal of Diabetes and Metabolic Disorders, 2021
Hamideh Moosapour   +4 more
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

MEDICINE AND CLINICAL PATHOLOGY [PDF]

open access: yesBMJ, 1917
P W, Bassett-Smith, H D, Rolleston
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Near fatal eosinophilic gastroenteritis responding to oral sodium chromoglycate.

open access: yesGut, 1988
R. J. Moots   +4 more
semanticscholar   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Clinical medicine to social medicine

open access: yesIndustrial Psychiatry Journal, 2018
Bhat, PookalaShivaram   +3 more
openaire   +4 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Design and Validation of Clinical Education Curriculum Pattern Based on Social Accountability for General Medicine Course: A Mixed Method Study [PDF]

open access: yesPizhūhish dar Āmūzish-i ̒ulūm-i Pizishkī
Introduction: Curriculum Pattern Based on Social Accountability has important role on peopleʹs health and community. Unfortunately, In Iran's medical education system, there is a weakness in responding to the needs of society.
Gholamali Dehghani   +4 more
doaj  

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