Results 91 to 100 of about 16,573,156 (294)

SEMIOTICS, DIAGNOSTICS AND THERAPY TACTICS OF DEPRESSIVE DISORDERS IN CLINICAL MEDICINE

Бюллетень сибирской медицины, 2014
Study objectives are dedicated to brief synthesized establishment of diagnostics general standard, management and therapy of major depressive disorders (MDD) in clinical medicine to provide education in medical practice.Study methods are based on short ...
N. A. Kornetov
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

NLRP3 Inflammasome-Mediated Pyroptosis in Diabetic Nephropathy: Pathogenic Mechanisms and Therapeutic Targets

Journal of Inflammation Research
Yichao Chen,1 Riqiu Chen,2 Xiaozhen Ji,2 Zhifu Zeng,2 Changrong Guan2 1School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, 310000, People’s Republic of China; 2Department of Endocrinology, The Lishui Hospital of Wenzhou Medical University,
Chen Y, Chen R, Ji X, Zeng Z, Guan C
doaj  

Japanese medical researchers’ perceptions of quantitative research evaluation metrics and their psychological well-being: a cross-sectional study

Environmental Health and Preventive Medicine
Background: Supporting the mental health of researchers is essential to maintaining human resources and advancing science. This study investigated the association between Japanese medical researchers’ perceptions of research evaluation processes and ...
Akira Minoura, Keisuke Kuwahara, Yuhei Shimada, Hiroko Fukushima, Makoto Kondo, Takehiro Sugiyama   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Characterization of Gastric Mucinous Carcinoma: Clinicopathological Insights and Vascular Features via MSCT

International Journal of General Medicine
Yueqi Huang,1,* Qingchun Li,2,* Liujun Li,1,* Mingqi Zhang,3 Yuchen Luo,3 Qian Shen,3 Shuai Xiao,3 Qiulin Huang3 1Department of Ultrasound Medicine, the First Affiliated Hospital, Hengyang Medical School, University of South China,
Huang Y, Li Q, Li L, Zhang M, Luo Y, Shen Q, Xiao S, Huang Q   +7 more
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From classification medicine to clinical medicine (late XVIII century 1870s) Communication 1. Early formulation of the new style of medical thinking (clinical thinking)

Терапевтический архив, 2011
This communication is devoted to appearance of a qualitatively different methodological approach to problems of practical medicine in 1890s. This approach gave rise to formation of a new style of medical thinking (clinical thinking) and development of ...
Andrey Mikhaylovich Stochik, Sergey Nargisovich Zatravkin, A M Stochik, S N Zatravkin   +3 more
doaj  

The application of artificial intelligence in medical clinics, scientific research and education

Guangxi Yike Daxue xuebao
In recent years, artificial intelligence (AI) has developed rapidly, and clinical medicine has also seen revolutionary changes. This study traces the development process of AI in clinical medicine and conducts an in-depth analysis through specific ...
Gang CHEN, Rongquan HE, Diyuan QIN, Rui LIN, Kejun WU, Jiandi LI, Yuxing TANG, Yongxiong HUANG, Jingwen LING, Jianjun LI, Yu LONG, Jing SU, Huimin HE   +12 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

From classification medicine to clinical medicine (the end of the XVIII century 1870s). Communication 2. The first stage of clinical medicine development: introduction of the method of clinico-anatomic correlations

Терапевтический архив, 2011
The first stage of clinical medicine development is analysed which covers the period from early 1800s to middle 1870s. Considered are basic research achievements associated with introduction of the method of clinico-anatomic correlations into practical ...
Andrey Mikhaylovich Stochik, Sergey Nargisovich Zatravkin, A M Stochik, S N Zatravkin   +3 more
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