Results 71 to 80 of about 4,829,298 (254)

To the 110^th anniversary of Academician D.D. Yablokov (1896—1993)

Бюллетень сибирской медицины, 2006
The article presents the understanding of scientific heritage of the prominent Russian clinician, founder of the Siberian school of physicians, Academician D.D. Yablokov, whose 110th jubilee took place on November of 2006.
R. S. Karpov
doaj  

Cerebrospinal fluid dynamics and brain function regulation: from homeostasis to neurological disorders

Frontiers in Neuroscience
Cerebrospinal fluid (CSF) is increasingly recognized as an active regulator of brain function rather than a passive mechanical buffer. Beyond its classical roles in cushioning the brain and removing metabolic waste, CSF participates in a tightly coupled ...
Yu Yang, Yu Yang, Yu Yang, Huixia Jia, Huixia Jia, Huixia Jia, He Liu, He Liu, He Liu   +8 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Interpreting the Essence of Medicine for Better Medical Diagnosis

Yixue yu zhexue
This paper outlines the origin, historical significance, and connotation of hermeneutics. From the perspective of hermeneutic philosophy, clinical medicine originates in questioning and observation.
Jianping ZONG
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Advances in applications of data annotation in public health and clinical medicine: a review

Zhongguo gonggong weisheng
Data annotation is the foundation for the application of artificial intelligence (AI). This paper reviews the real-world applications of data annotation in public health and clinical medicine, with the aim of providing reference for promoting the ...
Yijing LIU, Jingqi ZHANG
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Desxifrar sigles mèdiques en català amb ChatGPT, Gemini i Copilot : una anàlisi comparativa

BiD: Textos Universitaris de Biblioteconomia i Documentació
Objectius. Aquest estudi té com a objectiu avaluar la capacitat de tres xatbots d’intel·ligència artificial (IA) — ChatGPT, Gemini i Copilot— per desxifrar sigles mèdiques polisèmiques en català, tot analitzant la seva eficàcia en funció del context.
Adéla Kotatkova
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source