Results 71 to 80 of about 926,237 (299)

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Rapid Detection of KPC-Producing Enterobacterales Susceptible to Imipenem/Relebactam by Using the MALDI-TOF MS MBT STAR-Carba IVD Assay

Frontiers in Microbiology, 2020
KPC-producing Enterobacterales represent a serious public health concern. Limited therapeutic options are available for treatment, however, the novel combination of imipenem/relebactam represents a promising alternative.
Marina Oviaño, Eva Gato, Germán Bou
doaj   +1 more source

Molecular biology techniques as a tool for detection and characterisation of Mycobacterium avium subsp. paratuberculosis [PDF]

, 2002
Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis) is the causative agent of paratuberculosis, also known as Johne’s disease, a chronic intestinal infection in cattle and other ruminants.
Englund, Stina
core  

Consumed by Abdominal Distention

Arthritis Care &Research, EarlyView.
Abimbola Fadairo‐Azinge, James Grenert, Brian Haas, Mary Margaretten   +3 more
wiley   +1 more source

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

A summary of the main themes and findings presented at the ASM Intermountain Branch meeting (2024)

mSphere
The annual meeting for the Intermountain Branch was held in April 2024 on the campus of Brigham Young University. There were 127 branch members from Utah, Idaho, and Nevada who attended the meeting and were composed of undergraduate students, graduate or
Jay Radke, Javier Ochoa-Repåraz, Jamee Nixon, Sajal Acharya, Haley Bridgewater, Joshua Burger, Abigail Cheever, Robert Darby, William Doyle, Alka Gaur, Eva Githuku, Rose Goodman, Topher Haynie, Hannah Hedelius, Kristina Hill, Misha Iqbal, Salma Laabi, Carlos Moreno, Melinda Moss, Nagama Parveen, Naomi Rapier-Sharman, Sara Sadeghi, Saeed Saleh, Sean Schumacher, Miranda Sharp, Noah Souza, Soni Thapa, Shule Aggabao, David Amsbury, Sheena Isabelle Bautista, Atalie Bogh, Aaron Bohn, Cade Brink, B. Shaun Bryner, James Cannon, Scot Carrington, Hayzen Chamberlain, Alex Cherry, McKaylin Cole, Edgar Corrales, Caz Cullimore, Sophie Daines, Payson Danielson, Monterey Domike, Matthew East, Bronwyn Ellis, Taryn Evans, Zach Fears, Paige Fellars, Tate Fisher, Braxton Floyd, Trenton Gibson, Mason Gueller, Heather Gupta, Jacob Gwilliam, Mackenzie Hansen, Jacob Hardy, Christopher Harrell, Rebecca Hassell, Wesley Hendricks, Colby Hendrix, Hirsche Henstrom, Kelly Hernandez Sanguino, George Higgins, Hyunbi Hwang, Matt Jackson, Conner Jensen, Austin Johnson, Chloe Kang, Sehi Kim, Alexandra LaFollette, Phoenix Larsen, Abbey Larson, Bryson Leary, Jayden Longhurst, Michael Mann, Isreal Martinez, Brooklyn Matthews, Cody McStraw, Ninahazwe Mireill, Rachel Moffat, Peter Mourik, Madelyn Mudrow, Mailon Odell, Blake Oler, Natalie Olsen, Nazanin Paymard, Spencer T. Payne, Levi Pearson, Josh Peter, Tiffani Peterson, Daniel Puentes Navarro, Kyla Radke, Joseph Richardson, Russell Ridd, Akir Rowe, Rylan Schmanski, Jacob Scott, Samuel Scott, Mya Simpkins, Madalyne Sisk, Tyler Smith, Brinley Smith, Jacob Sy, Gisselle Trejo, Bartel Van Oostendorp, Ethan Walbom, Rebecca Whetten, Dallin Zollinger, Miriam Braunstein, Donald P. Breakwell, Anirban Chakraborty, Matthew Crook, Michele Culumber, Wayne Hatch, Victor M. Jimenez, Jr., Wales P. Nematollahi, Michael Olson, Mark Poritz, Seth Ririe, Jeffrey Schachterle, Lisa Wiltbank, Todd Kelson, Brett E. Pickett   +123 more
doaj   +1 more source

Presence of Waddlia chondrophila in hot water systems from non-domestic buildings in France [PDF]

, 2018
Postprint (author's final ...
Agustí Adalid, Gemma, Codony Iglesias, Francesc, Humeau, Philippe, Le Calvez, Thomas, Trouilhé, Marie-Cecile   +4 more
core   +2 more sources

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source