Results 91 to 100 of about 5,839,126 (286)

Guiding the Clinical Nurse Specialist role in oncology within Princess Margaret Cancer Centre. [PDF]

Can Oncol Nurs J, 2022
Cheung V, Brown J, Julius A, Mitchell L, Moura S, Jin R.   +5 more
europepmc   +1 more source

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

Advanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang   +9 more
wiley   +1 more source

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

Advanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger, Matthew R. DeWitt, Carly M. Van Wagoner, Claire A. Conarroe, Charles C. Funk, Aaron B. Streit, AeRyon Kim, Richard J. Price, Timothy N. J. Bullock   +8 more
wiley   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Changing the conversation: impact of guidelines designed to optimize interprofessional facilitation of simulation-based team training

Advances in Simulation
Background Interprofessional simulation-based team training (ISBTT) is commonly used to optimize interprofessional teamwork in healthcare. The literature documents the benefits of ISBTT, yet effective interprofessional collaboration continues to be ...
Mindy Ju, Naike Bochatay, Alexander Werne, Jenna Essakow, Lisa Tsang, Mary Nottingham, Deborah Franzon, Audrey Lyndon, Sandrijn van Schaik   +8 more
doaj   +1 more source

Clinical nurse specialist role in providing generalist and specialist palliative care: A qualitative study of mesothelioma clinical nurse specialists. [PDF]

J Adv Nurs, 2022
Gardiner C, Harrison M, Hargreaves S, Taylor B.   +3 more
europepmc   +1 more source

The role of the clinical nurse specialist in caring for patients with prostate cancer: a narrative review

, 2014
Maria Helena Baena de Moraes Lopes,1 Rosângela Higa21Faculty of Nursing, University of Campinas, Campinas, São Paulo, Brazil; 2Nursing Department, Prof Dr José Aristodemo Pinotti Women’s Hospital, CAISM, University of Campinas ...
Higa R, Lopes MH
core  

An exploratory study for the development of emergency nurse practitioner specialist clinical practice standards [PDF]

, 2014
This thesis presents a mixed methods study to develop specialty specific clinical practice standards for Emergency Nurse Practitioners. This is the first time in Australia that Nurse Practitioners standards have been developed for a clinical specialty ...
O'Connell, Jane
core  

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Clinical Nurse Specialist Impact on COVID-19 Preparation at a Military Treatment Facility. [PDF]

Clin Nurse Spec, 2021
Lucciola ME, Nelson NM, Rea JM, Boudreaux AJ, Fedderson DJ, Hodge NS.   +5 more
europepmc   +1 more source