Results 41 to 50 of about 80,892 (260)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
A Study on the Qualifications and Ways of Selecting Candidates of Clinical Nurse Specialist in China
Huli yanjiu, 2003 Objective: to understand the viewpoints of nursing staffs towards the essential qualifications and ways of selecting candidates of clinical nurse specialists in our country, and to provide a basis for the establishment of an eligible criteria for ...
王欣, 王惠珍
doaj
Frontiers in MedicineBackgroundInflammatory bowel disease (IBD) is a chronic condition characterized by the need for highly individualized treatment plans, requiring patients to make numerous complex medical decisions.
Shuyan Li +7 more
doaj +1 more source
BMC Health Services Research, 2020 Background Extensive measures to reduce person-to-person transmission of COVID-19 are required to control the current outbreak. Special attention is directed at healthcare professionals as reducing the risk of infection in healthcare is essential.
Malene Missel +4 more
doaj +1 more source
Advanced Practice Nursing Roles, Regulation, Education, and Practice: A Global Study
Annals of Global Health, 2022 Background and Objectives: Several subgroups of the International Council of Nurses Nurse Practitioner/Advanced Practice Nurse Network (ICN NP/APNN) have periodically analyzed APN (nurse practitioner and clinical nurse specialist) development around the ...
Kathy J. Wheeler +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
The role of the clinical nurse specialist in haemoglobinopathies
Thalassemia Reports, 2018 The role of the Clinical Nurse Specialist (CNS) is an everdeveloping role that is integral in the care of individuals with haemoglobinopathies. Haemoglobinopathies are complex disorders that require specialist knowledge to deliver the very best care.
Bernadette Hylton
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Perspectives on Specialist Nursing in Saudi Arabia: A National Model for Success
Annals of Saudi Medicine, 2012 In many parts of the world, vulnerable patient populations may be cared for by a clinical nurse specialist (CNS). Nurses desiring to develop themselves professionally in the clinical arena, within the specialty of their choice, have the opportunity to ...
Denise Hibbert +2 more
doaj +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source