Results 191 to 200 of about 1,464,129 (347)

Impact of 2017 American Society of Clinical Oncology Guidelines on Postanthracycline Cardiac Surveillance Practices. [PDF]

JACC Adv
Zheng C, Spetko N, Liang L, Song Y, Hoeger CW, Gong J, Leukam M, Schlam I, Upshaw JN, Strom JB.   +9 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Mismatch Between Preclinical Cardio-Oncology and Clinical Oncology Research. [PDF]

JACC CardioOncol
Cagnazzo R, Stabile M, Zoppoli G, De Boer RA, Meijers WC, van Der Meer P, Ameri P.   +6 more
europepmc   +1 more source

Clinical Application of Active Aspiration Fluid Biopsy for Pancreatic Neoplasia Diagnosis in Oncology Practice

Алексей Ариевич Кашинцев, Николай Юрьевич Коханенко, Константин Вадимович Павелец, Иван Анатольевич Соловьев, Дмитрий Сергеевич Русанов, Ольга Григорьевна Вавилова, Юрий Васильевич Радионов, Михаил Сергеевич Диникин, Михаил Юрьевич Агапов, Yu. V. Pelipas, Юрий Алексеевич Гуляев, Темури Шокроевич Моргошия, Фарида Габдрахманова Магомедова, Людмила Александровна Соловьева, Анастасия Андреевна Надеева, Анна Сергеевна Боровикова, Кирилл Владимирович Лаптев, Александр Васильевич Лемешев, Виталий Юрьевич Пруцкий   +18 more
openalex   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Case Report: Pitfalls in anatomic pathology and clinical oncology: a case of misdiagnosed pulmonary Ewing sarcoma as SCLC. [PDF]

Front Oncol
El Waary NS, Chami AA, Zrein JK, Houcheimy DA, Akl RT, Fleifel SD, Kamar FG.   +6 more
europepmc   +1 more source

Evaluating a Video-Based, Personalized Webpage in Genitourinary Oncology Clinical Trials: A Phase 2 Randomized Trial [PDF]

, 2018
Rana R. McKay, Hannah Mills, Lillian Werner, Atish D. Choudhury, Toni K. Choueiri, Susanna Jacobus, Amanda F. Pace, L Polácek, Mark M. Pomerantz, Judith Prisby, Christopher J. Sweeney, Meghara Walsh, Mary‐Ellen Taplin   +12 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Immunotherapy to Address Unmet Needs in Oncology; Two Clinical Vignettes of Response in Metastatic Malignant Melanoma and Non-Small Cell Lung Cancer

, 2015
Arafat Tfayli, Mohammad Nami, Atabak Ghotb   +2 more
openalex   +1 more source

Liquid biopsies in clinical oncology: Review of validation results [PDF]

, 2017
Kushal Gupta, Arun Chougule, VL Ramprasad, Vanita Noronha, Amit Joshi, Vijay Patil, Vidya Veldore, Kumar Prabhash   +7 more
openalex   +1 more source