Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh+5 more
wiley +1 more source
Japan society of clinical oncology position paper on appropriate clinical use of molecular residual disease (MRD) testing. [PDF]
Kobayashi S+20 more
europepmc +1 more source
Acute Myeloid Leukemia Clinical Practice Guidelines in Oncology [PDF]
openalex +1 more source
Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza+5 more
wiley +1 more source
Analytical and Clinical Validation of Solo-Test Driver: A Targeted Amplicon-Based NGS Test-System for FFPE and cfDNA Analysis in Clinical Oncology Setting. [PDF]
Ivanov M+20 more
europepmc +1 more source
American Society of Clinical Oncology Treatment of Unresectable Non–Small-Cell Lung Cancer Guideline: Update 2003 [PDF]
David G. Pfister+10 more
openalex +1 more source
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha+10 more
wiley +1 more source
Chinese Society of Clinical Oncology (CSCO) Breast Cancer guidelines 2024. [PDF]
Li J+16 more
europepmc +1 more source
Is Patient Travel Distance Associated With Survival on Phase II Clinical Trials in Oncology? [PDF]
Elizabeth B. Lamont+9 more
openalex +1 more source