Results 151 to 160 of about 17,262,511 (380)

Review of Positron Emission Tomography at Royal Prince Alfred Hospital, CHERE Project Report No 18 [PDF]

This report is a review of the clinical uses, impacts on clinical management, clinical outcome and resource use of Positron Emission Tomography (PET) at Royal Prince Alfred Hospital (RPAH).Positron emission ...
Anastasia Lowin, Christine Pollicino, Michael Fulham, Phil Haywood, Rosalie viney   +4 more
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Transcriptome Profiling of Circulating Tumor Cells to Predict Clinical Outcomes in Metastatic Castration-Resistant Prostate Cancer [PDF]

, 2023
Levi Groen, Iris S. H. Kloots, David Englert, Kelly Seto, Lana Estafanos, P. Smith, Gerald W. Verhaegh, Niven Mehra, Jack A. Schalken   +8 more
openalex   +1 more source

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.

Cell Stem Cell, 2007
C. Ginestier, M. Hur, E. Charafe-Jauffret, F. Monville, J. Dutcher, Marty Brown, J. Jacquemier, P. Viens, C. Kleer, Suling Liu, A. Schott, D. Hayes, D. Birnbaum, M. Wicha, G. Dontu   +14 more
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Clinical outcome measurement [PDF]

British Journal of Psychiatry, 1999
openaire   +2 more sources

Clinical Characteristics and Treatment Outcomes of COVID-19 Patients at Eka Kotebe General Hospital, Addis Ababa, Ethiopia [PDF]

, 2022
Dawit Kebede Huluka, Eyob Kebede Etissa, Sebrina Ahmed, Hiluf Abate Abule, Nebiyu Getachew, Sisay Abera, Abebaw Bekele Seyoum, Hiruy Araya, Tsegaye Gebreyes, Bethlehem Tadesse Anteneh, Getachew Gebremedhin, Yonas Gebregziabher, Rediet Yitagesu Tefera, Addisu Birhanu Tereda, Yohannes Feleke, Yonathan Abebe, Tewodros Haile Gebremariam, H.Y. Ahmed, Wondwossen Amogne, D.A. Haisch, Charles B. Sherman, Neil W. Schluger   +21 more
openalex   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source