Results 181 to 190 of about 17,262,511 (380)

A Clinical and Analytical Study of Surgical and Patient-Centered Outcomes of Open Haemorrhoidectomy and Chivate's Procedure at a Tertiary Care Centre in Central India [PDF]

Ashok Kalbi, Ganesh Kharkate, Raj Gajbhiye   +2 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

miRNA-seq and clinical evaluation in multiple myeloma: miR-181a overexpression predicts short-term disease progression and poor post-treatment outcome

, 2021
M. Papadimitriou, Αριστέα-Μαρία Παπανώτα, Panagiotis G. Adamopoulos, Katerina‐Marina Pilala, Christine‐Ivy Liacos, Panagiotis Malandrakis, Nefeli Mavrianou‐Koutsoukou, Dimitrios Patseas, Evangelos Eleutherakis‐Papaiakovou, Maria Gavriatopoulou, Efstathios Kastritis, Margaritis Avgeris, Meletios Α. Dimopoulos, Evangelos Terpos, Andreas Scorilas   +14 more
openalex   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Radiotherapy Protocol Deviations and Clinical Outcomes: A Meta-analysis of Cooperative Group Clinical Trials [PDF]

, 2013
Nitin Ohri, Xinglei Shen, Adam P. Dicker, L. A. Doyle, A. Harrison, Timothy N. Showalter   +5 more
openalex   +1 more source

Comparative study on clinical outcomes and cost-effectiveness of chronic subdural hematomas treated by middle meningeal artery embolization and conventional treatment: a national cross-sectional study

, 2023
Xin Tong, Xiaopeng Xue, Aihua Liu, Peng Qi   +3 more
openalex   +1 more source

Disease severity and minimal clinically important differences in clinical outcome assessments for Alzheimer's disease clinical trials

Alzheimer's & Dementia, 2019
J. Andrews, U. Desai, N. Kirson, M. Zichlin, Daniel E. Ball, Brandy R. Matthews   +5 more
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Red blood cell storage duration is not associated with clinical outcomes for acute chest syndrome in children with sickle cell disease

, 2015
Melanie E. Fields, Monica L. Hulbert, Ling Chen, Ari N. Berlin, Ron Jackups, Philip C. Spinella   +5 more
openalex   +2 more sources