Results 141 to 150 of about 2,569,145 (337)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Management of Sporadic Vestibular Schwannomas in Children-Volumetric Analysis and Clinical Outcome Assessment. [PDF]

Children (Basel), 2022
Zipfel J, Gorbachuk M, Gugel I, Tatagiba M, Schuhmann MU.   +4 more
europepmc   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The predictive value of GLIM criteria on clinical outcomes and responses to nutritional support in patients with neurocritical illnesses

Scientific Reports
Neurocritically ill patients frequently exhibit coma, gastroparesis, and intense catabolism, leading to an increased risk of malnutrition. The Global Leadership Initiative on Malnutrition (GLIM) criteria for the diagnosis of malnutrition was created to ...
Peiqi Liu, Huimin Tian, Lan Gao, Tangsheng Zhong, Yujiao Wang, Li Chen   +5 more
doaj   +1 more source

A Guide to the Language of Clinical Outcome Assessment. [PDF]

Global Spine J, 2021
Dettori JR, Norvell DC, Chapman JR.
europepmc   +1 more source

Clinical Outcome Assessments in FDA Oncology Labels Since 2010 [PDF]

, 2013
Oren Meyers, Kimberley Foley
openalex   +1 more source

Clinical Interpretation of Efficacy Outcomes in Pharmacological Studies on Triple Fixed-Dose Combination Therapy for Uncontrolled Asthma: Assessment of IRIDIUM and ARGON Studies

, 2022
Paola Rogliani, Luigino Calzetta
openalex   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Minimal Clinically Important Difference (MCID) of Effect Sizes other than Mean Difference

Journal of Clinical Question
It is recommended to report both a P value < 0.05 and an effect size exceeding the minimal clinically important difference (MCID) to assert a meaningful difference or association between two clinical measurements.
Nobuyuki Horita, Shota Yamamoto, Yuki Mizuki, Tatsukata Kawagoe, Takahiro Mihara, Tsuneo Yamashiro   +5 more
doaj   +1 more source