Results 151 to 160 of about 2,569,145 (337)

Clinical Outcome Assessment in Cancer Rehabilitation and the Central Role of Patient-Reported Outcomes. [PDF]

Cancers (Basel), 2021
Lehmann J, Rothmund M, Riedl D, Rumpold G, Grote V, Fischer MJ, Holzner B.   +6 more
europepmc   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Revisiting defense mechanisms in contemporary clinical practice: evidence and perspectives

Research in Psychotherapy
The paper revisits defense mechanisms as central regulators of emotional life and self-coherence in contemporary clinical practice, showing how a classical psychodynamic construct has evolved into an empirically measurable, transdiagnostic dimension of ...
Vittorio Lingiardi, Fabio Madeddu
doaj   +1 more source

A non-interventional observational study to identify and validate clinical outcome assessments for adults with phenylketonuria for use in clinical trials

, 2021
Barbara K. Burton, Anne Skalicky, Christoph Baerwald, Deborah A. Bilder, Cary O. Harding, Aaron B. Ilan, Elaina Jurecki, Nicola Longo, David T. Madden, Serap Sivri, Gisela Wilcox, Janet A. Thomas, Kathleen Delaney   +12 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

PROMs data: can it be used to make decisions for individual patients? A narrative review

Patient Related Outcome Measures, 2019
Jonathan Field,1 Michelle M Holmes,2,3 Dave Newell3,41Back Active, Southsea, Hampshire, UK; 2Department of Psychology, University of Southampton, Southampton, Hampshire, UK; 3AECC University College, Bournemouth, Dorset, UK; 4Centre for Primary Care and ...
Field J, Holmes MM, Newell D
doaj  

Best Practice Recommendations: User Acceptance Testing for Systems Designed to Collect Clinical Outcome Assessment Data Electronically. [PDF]

Ther Innov Regul Sci, 2022
Gordon S, Crager J, Howry C, Barsdorf AI, Cohen J, Crescioni M, Dahya B, Delong P, Knaus C, Reasner DS, Vallow S, Zarzar K, Eremenco S, Electronic Patient-Reported (ePRO) Consortium, PRO Consortium.   +14 more
europepmc   +1 more source

Digital technologies as biomarkers, clinical outcomes assessment, and recruitment tools in Alzheimer's disease clinical trials [PDF]

, 2018
Michael Gold, Joan Amatniek, María C. Carrillo, Jesse M. Cedarbaum, James A. Hendrix, Bradley B. Miller, Julie M. Robillard, John Jeremy Rice, Holly Soares, Maria Tome, Ioannis Tarnanas, Gabriel Vargas, Lisa J. Bain, Sara J. Czaja   +13 more
openalex   +1 more source

Real-World Assessment of Clinical Outcomes Among First-Line Sunitinib Patients with Clear Cell Metastatic Renal Cell Carcinoma (mRCC) by the International mRCC Database Consortium Risk Group [PDF]

, 2020
Marie-France Savard, J. Connor Wells, Jeffrey Graham, Shaan Dudani, John A. Steinharter, Bradley A. McGregor, Frede Donskov, Georg A. Bjarnason, Ulka N. Vaishampayan, Aaron R. Hansen, Marco Iafolla, Giovanni Zanotti, Lynn Huynh, Rose Chang, Mei Sheng Duh, Daniel Y.C. Heng   +15 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source