Results 161 to 170 of about 2,569,145 (337)

Thymidylate Synthase Expression and Outcome of Patients Receiving Pemetrexed for Advanced Nonsquamous Non–Small-Cell Lung Cancer in a Prospective Blinded Assessment Phase II Clinical Trial [PDF]

, 2013
M. Nicolson, Dean A. Fennell, David Ferry, Kenneth J. O’Byrne, Riyaz Shah, Vanessa Potter, G. Skailes, Sunil Upadhyay, Paul Taylor, Valérie André, Tuan S. Nguyen, Scott P. Myrand, Carla Visseren‐Grul, Mayukh Das, Keith M. Kerr   +14 more
openalex   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Clinical outcome, risk assessment, and seasonal variation in hospitalized COVID-19 patients—Results from the CORONA Germany study

, 2021
Nele Geßler, Melanie Gunawardene, Peter Wohlmuth, Dirk Arnold, Jürgen Behr, Christian Johannes Gloeckner, Klaus Herrlinger, Thomas Hoelting, Ulrich‐Frank Pape, Ruediger Schreiber, Axel Stang, Claas Wesseler, Stephan Willems, Charlotte Arms, Christoph U. Herborn   +14 more
openalex   +2 more sources

Clinical Outcome Assessment [PDF]

, 2020
openaire   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Quantitative Assessment of Interim PET/CT Could Have More Prognostic Relevance than Visual Assessment for Predicting Clinical Outcome of Extranodal Diffuse Large B Cell Lymphoma [PDF]

, 2020
Dong Won Baek, Hee Jeong Cho, Ju-Hyung Kim, Sang Kyun Sohn, Ga‐Young Song, Seo‐Yeon Ahn, Sung‐Hoon Jung, Jae Sook Ahn, Je‐Jung Lee, Hyeoung‐Joon Kim, Shin-Young Jeong, Chae Moon Hong, Jung‐Joon Min, Joon Ho Moon, Deok‐Hwan Yang   +14 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Swedish trial on embolization of middle meningeal artery versus surgical evacuation in chronic subdural hematoma (SWEMMA)-a national 12-month multi-center randomized controlled superiority trial with parallel group assignment, open treatment allocation and blinded clinical outcome assessment. [PDF]

Trials, 2022
Drake M, Ullberg T, Nittby H, Marklund N, Wassélius J.   +4 more
europepmc   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Clinical Outcome Assessments for Spasticity: Review, Critique, and Recommendations [PDF]

Ota Gál, Marjolaine Baude, Thierry Deltombe, Alberto Esquenazi, Jean‐Michel Graciès, Martina Hoskovcová, Carmen Rodríguez‐Blázquez, Raymond L. Rosales, Lalith Satkunam, Jörg Wissel, Tiago Mestre, Álvaro Sánchez‐Ferro, Matěj Škorvánek, Michelle Hyczy de Siqueira Tosin, Robert Jech   +14 more
openalex   +1 more source