Results 191 to 200 of about 2,569,145 (337)

Priority acute and preventive migraine treatment benefits: Results of the Migraine Clinical Outcome Assessment System (MiCOAS) qualitative study of people living with migraine [PDF]

, 2023
Rikki Mangrum, Maya T. Gerstein, Calvin J. Hall, Dawn C. Buse, Carrie R. Houts, James S. McGinley, Kelly P. McCarrier, Richard B. Lipton, R. J. Wirth   +8 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Traumatic brain injury: support for injured people and their carers [PDF]

Provides a summary of the available evidence for assessing traumatic brain injury (TBI) and managing the common mental health, physical and cognitive/behavioural issues associated with TBI.
Ian Cameron, Jagnoor Jagnoor
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Clinical Outcome Assessment Tools for Evaluating the Management of Gliomas. [PDF]

Cancers (Basel)
Chakravarti S, Gupta SR, Myneni S, Elshareif M, Rogers JL, Caraway C, Ahmed AK, Schreck KC, Kamson DO, Holdhoff M, Croog V, Redmond KJ, Bettegowda C, Mukherjee D.   +13 more
europepmc   +1 more source

Assessment of pSOFA-L score in predicting the clinical outcome of critically ill children

, 2020
Shrishail Kumbar, Chandrashekhara
openalex   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Development of a novel clinical outcome assessment: digital instrumental activities of daily living. [PDF]

EBioMedicine
Sawyer A, Brannigan J, Spielman L, BCI Functional Outcome Measures Group, Putrino D, Fry A.   +5 more
europepmc   +1 more source

Analysis of a Urinary Biomarker Panel for Clinical Outcomes Assessment in Cirrhosis

, 2015
Xavier Ariza, Elsa Solà, Chiara Elia, Rogelio Barreto, Rebeca Moreira, Manuel Morales‐Ruiz, Isabel Graupera, Ezequiel Rodríguez, Patrícia Huelin, Cristina Solé, Javier Fernández, Wladimiro Jiménez, Vicente Arroyo, Pere Ginès   +13 more
openalex   +2 more sources

Clinical Outcome Assessment Criterion Validation [PDF]

, 2020
openaire   +1 more source